Parazox 500 mg (Tablet)

Indications

• Treatment of diarrhea caused by Cryptosporidium parvum
• Treatment of diarrhea caused by Giardia lamblia
• Treatment of diarrhea caused by Entamoeba histolytica

Pharmacology

• Synthetic antiprotozoal agent for oral administration
• Interference with the Pyruvate Ferredoxin Oxido Reductase (PFOR) enzyme-dependant electron transfer reaction
• Inhibiting the growth of sporozoites and oocyst of Cryptosporidium parvum
• Inhibiting the growth of trophozoites of Giardia lamblia

Dosage & Administration

• Dosage for Age 1-3 years: 1 tea-spoonfull or 5 ml suspension every 12 hours for 3 days
• Dosage for Age 4-11 years: 2 tea-spoonfulls or 10 ml suspension every 12 hours for 3 days
• Dosage for Age 12 years or above: 5 tea-spoonfulls (25 ml) suspension or 1 tablet every 12 hours for 3 days
• Recommended to be administered with food

Interaction

• Highly bound to plasma protein
• Caution when administering concurrently with other highly plasma protein-bound drugs with narrow therapeutic index

Contraindications

• Known hypersensitivity to Nitazoxanide or any components of the preparation

Side Effects

• Frequent side effects include abdominal pain, vomiting and headache
• Rare side effects include nausea, anorexia, flatulence, increased appetite, enlarged salivary glands, increased creatinine & SGPT level, pruritus, rhinitis, sweating, dizziness, discolored urine

Pregnancy & Lactation

• US FDA pregnancy category of Nitazoxanide is B
• No adequate and well-controlled studies in pregnant women
• Use during pregnancy only if clearly needed
• Excreted in human milk
• Caution during lactation

Precautions & Warnings

• Administer with caution to patients with hepatic & biliary disease
• Administer with caution to patients with renal disease

Therapeutic Class

• Anti-diarrhoeal
• Antiprotozoal

Storage Conditions

• Keep in a dry place away from light and heat
• Keep out of the reach of children

Related Brands