Arnivas 49 mg+51 mg (Tablet)
Unit Price: ৳ 80.00 (1 x 10: ৳ 800.00)
Strip Price: ৳ 800.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Sacubitril valsartan |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Reduce risk of cardiovascular death
- Treat symptomatic heart failure
- Administered with other heart failure therapies
Pharmacology
- Contains neprilysin inhibitor and angiotensin receptor blocker
- Increases levels of peptides degraded by neprilysin
- Inhibits effects of angiotensin II
Dosage & Administration
- Starting dose for adults: 49/51 mg orally twice daily
- Target maintenance dose for adults: 97/103 mg twice daily
- Recommended dose for pediatric patients according to weight
Interaction
- Dual blockade of the Renin-Angiotensin-Aldosterone System
- Potassium-sparing Diuretics may impact serum potassium level
- NSAIDs may increase risk of renal impairment
- Lithium increases risk of toxicity
Contraindications
- Hypersensitivity to any component
- History of angioedema related to previous ACE inhibitor or ARB therapy
- Concomitant use of ACE inhibitors or aliskiren in patients with diabetes
Side Effects
- Angioedema
- Hypotension
- Impaired Renal Function
- Hyperkalemia
- Cough
- Dizziness
Pregnancy & Lactation
- Not established in pediatric patients less than 1 year of age
- No relevant pharmacokinetic differences in elderly patients
- Dose adjustment for hepatic and renal impairment
Precautions & Warnings
- May cause angioedema
- Lowers blood pressure and may cause symptomatic hypotension
- Monitor serum potassium levels and treat appropriately
Use in Special Populations
- Safety and effectiveness not established in pediatric patients
- No relevant pharmacokinetic differences in elderly patients
- Dose adjustments for renal and hepatic impairment
Overdose Effects
- Hypotension is likely result of overdosage
- Symptomatic treatment should be provided
- Unlikely to be removed by hemodialysis
Storage Conditions
- Keep in dry place
- Store below 30°C
- Protect from moisture
- Keep out of reach of children