Arnivas 49 mg+51 mg (Tablet)

Unit Price: ৳ 80.00 (1 x 10: ৳ 800.00)
Strip Price: ৳ 800.00

Medicine Details

Indications

  • Reduce risk of cardiovascular death
  • Treat symptomatic heart failure
  • Administered with other heart failure therapies

Pharmacology

  • Contains neprilysin inhibitor and angiotensin receptor blocker
  • Increases levels of peptides degraded by neprilysin
  • Inhibits effects of angiotensin II

Dosage & Administration

  • Starting dose for adults: 49/51 mg orally twice daily
  • Target maintenance dose for adults: 97/103 mg twice daily
  • Recommended dose for pediatric patients according to weight

Interaction

  • Dual blockade of the Renin-Angiotensin-Aldosterone System
  • Potassium-sparing Diuretics may impact serum potassium level
  • NSAIDs may increase risk of renal impairment
  • Lithium increases risk of toxicity

Contraindications

  • Hypersensitivity to any component
  • History of angioedema related to previous ACE inhibitor or ARB therapy
  • Concomitant use of ACE inhibitors or aliskiren in patients with diabetes

Side Effects

  • Angioedema
  • Hypotension
  • Impaired Renal Function
  • Hyperkalemia
  • Cough
  • Dizziness

Pregnancy & Lactation

  • Not established in pediatric patients less than 1 year of age
  • No relevant pharmacokinetic differences in elderly patients
  • Dose adjustment for hepatic and renal impairment

Precautions & Warnings

  • May cause angioedema
  • Lowers blood pressure and may cause symptomatic hypotension
  • Monitor serum potassium levels and treat appropriately

Use in Special Populations

  • Safety and effectiveness not established in pediatric patients
  • No relevant pharmacokinetic differences in elderly patients
  • Dose adjustments for renal and hepatic impairment

Overdose Effects

  • Hypotension is likely result of overdosage
  • Symptomatic treatment should be provided
  • Unlikely to be removed by hemodialysis

Storage Conditions

  • Keep in dry place
  • Store below 30°C
  • Protect from moisture
  • Keep out of reach of children

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