Orneb 2.5 mg (Tablet)

Unit Price: ৳ 7.00 (5 x 10: ৳ 350.00)
Strip Price: ৳ 70.00

Medicine Details

Category Details
Generic Nebivolol hydrochloride
Company Ibn sina pharmaceuticals ltd
Also available as
Orneb 5 mg tablet

Indications

  • Hypertension
  • Treatment of essential hypertension
  • Chronic heart failure (CHF)
  • Treatment of stable mild and moderate chronic heart failure in elderly patients

Pharmacology

  • β adrenergic receptor blocking agent
  • Inhibits both β1 and β1 adrenergic receptors
  • Lacks intrinsic sympathomimetic and membrane stabilizing activity
  • Decreased heart rate
  • Decreased myocardial contractility
  • Diminution of tonic sympathetic outflow to the periphery from cerebral vasomotor centers
  • Suppression of renin activity
  • Vasodilation and decreased peripheral vascular resistance
  • Metabolized by glucuronidation and hydroxylation by CYP2D6
  • Mean peak plasma nebivolol concentrations occur approximately 1.5 to 4 hours post-dosing
  • Predominantly metabolized via direct glucuronidation
  • Concomitant administration with digoxin and warfarin

Dosage & Administration

  • Recommended starting dose of 5 mg once daily
  • Dose can be increased at 2-week intervals up to 40 mg
  • May be administered with or without food
  • More frequent dosing unlikely to be beneficial

Interaction

  • Use with care when myocardial depressants or inhibitors of AV conduction are used concurrently
  • Should not be combined with other β-blockers
  • Patients receiving catecholamine-depleting drugs should be closely monitored

Contraindications

  • Severe bradycardia
  • Heart block greater than first degree
  • Cardiogenic shock
  • Decompensated cardiac failure
  • Sick sinus syndrome (unless a permanent pacemaker is in place)
  • Severe hepatic impairment
  • Hypersensitivity to any component of the product

Side Effects

  • Headache
  • Nausea
  • Bradycardia

Precautions & Warnings

  • Abrupt cessation of therapy
  • Cardiac failure
  • Angina and acute myocardial infarction
  • Bronchospastic diseases
  • Anesthesia and major surgery
  • Diabetes and hypoglycemia
  • Thyrotoxicosis
  • Peripheral vascular disease
  • Non-dihydropyridine calcium channel blockers
  • Use in patients with impaired renal function
  • Risk of anaphylactic reactions

Use in Special Populations

  • Caution in patients with severe renal impairment
  • Caution in patients with moderate hepatic impairment
  • Risk of anaphylactic reactions in patients with history of severe reactions to allergens

Therapeutic Class

  • Beta-adrenoceptor blocking drugs
  • Beta-blockers

Storage Conditions

  • Keep below 30°C temperature
  • Away from light & moisture
  • Keep out of the reach of children

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