Esloric 300 mg (Tablet)
Unit Price: ৳ 8.30 (3 x 10: ৳ 249.00)
Strip Price: ৳ 83.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Allopurinol |
| Company | Square pharmaceuticals plc |
| Also available as |
Indications
- Reduction of urate/uric acid formation
- Management of gouty arthritis
- Treatment of 2,8-dihydroxyadenine (2,8-DHA) renal stones
- Management of recurrent mixed calcium oxalate renal stones
Pharmacology
- Xanthine oxidase inhibitor
- Orally administered
- Reduces production of uric acid
- Inhibits biochemical reactions
- Approximately 90% absorbed from GI tract
- Peak plasma levels at 1.5 to 4.5 hours
- Plasma half-life of 1 to 2 hours
Dosage & Administration
- Initial dosage of 100 mg/day
- Dosage adjustment based on serum urate response
- Different dosage schedules for adults based on severity
- Dosage for children under 15 years
- Dosage adjustment for elderly and renal impairment
Interaction
- Interaction with 6-mercaptopurine and azathioprine
- Potential impact on vidarabine and theophylline levels
- Enhanced toxic effects with concurrent use of specific drugs
Contraindications
- Contra-indicated in known hypersensitivity to allopurinol
Side Effects
- Rashes
- Gastrointestinal disorders
- Malaise
- Headache
- Vertigo
- Drowsiness
- Visual and test disturbances
- Hypertension
- Alopecia
- Hepatotoxicity
- Neuropathy
- Gynecomastia
- Blood disorders
Pregnancy & Lactation
- Inadequate evidence of safety in human pregnancy
- Use during pregnancy only when no safer alternative
- No data on effects on breast-fed baby
Precautions & Warnings
- Immediate withdrawal upon skin rash or sensitivity
- Reduced doses for patients with hepatic or renal impairment
- Caution in patients under treatment for hypertension or cardiac insufficiency
Overdose Effects
- Reported ingestion of up to 22.5 g without adverse effects
- Symptoms including nausea, vomiting, diarrhea, and dizziness
- Adequate hydration and potential use of hemodialysis
Therapeutic Class
- Drugs used in Gout
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of reach of children