Glycenor M ER 5 mg+1000 mg (Tablet (Extended Release))
Unit Price: ৳ 30.00 (3 x 6: ৳ 540.00)
Strip Price: ৳ 180.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Empagliflozin metformin hydrochloride |
| Company | Popular pharmaceuticals ltd |
| Also available as |
Indications
- Indicated for the treatment of adults with type 2 diabetes mellitus
- Adjunct to diet and exercise
- Treatment in combination with other medicinal products for diabetes
- Usable in patients uncontrolled with Metformin
- Usable in patients with volume depletion
Pharmacology
- Empagliflozin is an inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
- Metformin Hydrochloride is a biguanide type oral antihyperglycemic drug
- Empagliflozin reduces renal reabsorption of filtered glucose
- Metformin Hydrochloride decreases hepatic glucose production
- Metformin Hydrochloride lowers postprandial plasma glucose
Dosage & Administration
- Should be individualized based on effectiveness and tolerability
- Should be taken twice daily with meals
- Dose escalation should be gradual
- Extended-release formulations available
- Renal impaired patient assessment required
Interaction
- Interacts with diuretics
- Interacts with insulin or insulin secretagogues
- Monitor glycemic control with alternative methods
- Drugs that reduce Metformin clearance may increase its accumulation
- Alcohol can potentiate the effect of Metformin on lactate metabolism
Contraindications
- Hypersensitivity to Empagliflozin and Metformin
- Severe renal failure (GFR <30 ml/min)
- Acute metabolic acidosis or diabetic pre-coma
- Severe conditions altering renal function
Side Effects
- Common adverse reactions include urinary tract infection and genital mycotic infections
- Most common adverse reactions associated with Metformin are diarrhea, nausea, and abdominal discomfort
- Other adverse reactions include hypoglycemia, increased urination, and increased serum lipids
Pregnancy & Lactation
- Not recommended during pregnancy
- Advice against use when breastfeeding
Precautions & Warnings
- Lactic acidosis may occur
- Assess and correct volume status before initiation
- Monitor for signs and symptoms of hypotension
- Evaluate patients for signs of urinary tract infections
- Consider lowering the dose of insulin to reduce hypoglycemia risk
Overdose Effects
- No toxicity shown with single doses of up to 800 mg Empagliflozin
- No hypoglycemia seen with Metformin doses of up to 85 g
- Lactic acidosis may occur in overdose situations
Therapeutic Class
- Combination Oral hypoglycemic preparations
Storage Conditions
- Store below 30°C temperature
- Protect from light & moisture
- Keep out of the reach of children