Oroxat 70 mg (Tablet)
Unit Price: ৳ 400.00 (1 x 3: ৳ 1,200.00)
Strip Price: ৳ 1,200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Roxadustat |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of symptomatic anemia associated with chronic kidney disease (CKD)
Description
- Orally administered HIF-PH inhibitor
- Promotes erythropoiesis
- Improves iron regulation
- Reduces EPO-suppressive effects of inflammation
- Downregulates hepcidin
Pharmacology
- Orally bioavailable
- HIF prolyl hydroxylase inhibitor
- Increases endogenous erythropoietin production
- Reduces hepcidin expression
- Improves iron availability
- Boosts hemoglobin levels
Dosage & Administration
- Oral administration
- Taken three times per week
- Dose individualized for target Hb levels
- Different starting dosages based on weight
- Missed dose handling instructions
Interaction
- Potential drug interactions with phosphate binders, gemfibrozil, probenecid, and certain other medications
Side Effects
- Common adverse reactions include hypertension, vascular access thrombosis, diarrhea, peripheral edema, hyperkalemia, and nausea
Pregnancy & Lactation
- Contraindicated during pregnancy and lactation
Precautions & Warnings
- Caution in patients with risk factors for thrombotic vascular events
- Caution in patients with history of seizures
- Avoid in serious signs and symptoms of infection
- Avoid in patients with liver disorder
Use in Special Populations
- Not indicated for use in children
- Not recommended for use in patients with severe hepatic impairment
Overdose Effects
- Symptoms - increased heart rate
- Likely increase in hemoglobin concentration
- Treatment - appropriate measures of dose reduction or interruption
Therapeutic Class
- Drugs for Hemolytic, Hypoplastic, and Renal Anemia
Storage Conditions
- Store in a cool, dry place below 30°C
- Away from light and moisture