P-Tetracycline 250 mg (Capsule)
Unit Price: ৳ 1.30 (10 x 10: ৳ 130.00)
Strip Price: ৳ 13.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tetracycline hydrochloride oral |
| Company | Pristine pharmaceuticals ltd |
Indications
- Ricketsial infection (Rocky Mountain spotted fever, endemic and scrub typhus fever and human ehrlichiosis)
- Mycoplasma pneumoniae infections in adults
- Chlamydial Infections
- Non-gonococcal or non specific urethritis
- Lyme disease
- Brucellosis
- Miscellaneous infections including granuloma inguinale, cholera, glanders, relapsing fever and V. vulnifians
- Urinary Tract Infections with susceptible organisms
- Bronchitis in patients with known underlying chronic lung diseases
- Pelvic inflammatory disease and other sexually transmitted diseases (STDs) regimen
- Travelers diarrhoea
- Acne vulgaris
- Prostatitis
- As an alternative agent in the penicillin allergic patient with syphilis
- Anaerobic infections with susceptible organisms
Pharmacology
- Main mechanism of action on protein synthesis
- Energy-dependent active transport system
- Binds specifically to the 30s ribosomes
- Inhibits bacterial protein synthesis
- Gram positive aerobic Cocci susceptibility
- Resistance in staphylococci, streptococci and some pneumococci
- Resistance in Pseudomonas and many Enterobacteriaceae
- Active against Brucella species, Calymmatobacterium granulomatis, Vibrio cholerae and V. vulnificus
- Active against anaerobic species of bacteria
- Incompletely absorbed from the gastro-intestinal tract
- Half-life of about 12 hours
- Excreted in the urine and in the faeces
Dosage & Administration
- Usual adult oral dosage: 1-2 g daily given in 2-4 divided doses
- Usual oral dosage for children older than 8 years of age: 25-50 mg/kg daily given in 2-4 divided doses
- Acne vulgaris dosage:
- 250 mg four times daily
- 500 mg 12 hourly for 1 week
- 125-250 mg for several weeks or months
- Acute staphylococcal infections dosage: 1-2 g daily in divided doses for 10-14 days
- Acute streptococcal infections dosage: 1-2 g daily in divided doses for 10 days
- Amoebiasis dosage:
- 1 g daily in four divided doses
- 500 mg 12 hourly for 7 days
- Brucellosis dosage:
- 500 mg four times daily plus 1 g streptomycin twice daily for 1 week
- 500 mg four times daily (no streptomycin) for 1 week
- Subacute bacterial endocarditis dosage: 1-2 g daily in divided doses for 6 weeks
- Syphilis dosage: Total 30-40 g given in divided doses over 10-15 days
Interaction
- Impaired absorption with antacids containing divalent and trivalent cations
- May interfere with the bactericidal action of penicillin
- May potentiate the effect of anticoagulants
- May decrease efficacy of oral contraceptives
- Nephrotoxic effects may be exacerbated by diuretics or other nephrotoxic drugs
- May increase the hypoglycaemic effect of insulin and sulfonylureas in patients with DM
- May increase toxic effects of ergot alkaloids and methotrexate
Contraindications
- Hypersensitivity to any of the member of tetracycline groups
- Cross-sensitivity may occur
- Systemic lupus erythematosus
- Renal impairment, particularly if severe
Side Effects
- Depression of bone growth
- Permanent gray-brown discoloration of the teeth
- Enamel hypoplasia when given during tooth development
- Hypersensitivity reactions such as anaphylaxis, urticaria and rashes
- Photosensitivity reactions
- Gastrointestinal effects including epigastric distress, nausea and vomiting
- Accentuated prerenal azotemia
- Superinfections with oral and anogenital candidiasis
- Esophageal ulcerations
Pregnancy & Lactation
Should not be used during pregnancy because of the risk of hypertoxicity in the mother as well as the effects on the developing foetus.
Precautions & Warnings
Care should be taken if P-P-Tetracycline is given to patients with impaired liver function and high doses should be avoided.
Therapeutic Class
Tetracycline group of drugs
Storage Conditions
Store between 20-25°C