Dexamethason 0.5 mg (Tablet)

Unit Price: ৳ 0.40 (10 x 10: ৳ 40.00)

Strip Price: ৳ 4.00

Medicine Details

Category	Details
Generic	Dexamethasone
Company	Pristine pharmaceuticals ltd

Indications

Control of severe or incapacitating allergic conditions
Treatment of collagen diseases like lupus erythematosus and rheumatoid arthritis
Management of dermatologic diseases such as bullous dermatitis herpetiformis and pemphigus
Treatment for primary or secondary adrenocortical insufficiency
Management of gastrointestinal diseases like regional enteritis and ulcerative colitis
Treatment for leukemias and lymphomas
Management of nervous system disorders including acute exacerbations of multiple sclerosis
Induction of diuresis or remission of proteinuria in renal diseases
Use in respiratory diseases like berylliosis and fulminating pulmonary tuberculosis
Adjunctive therapy for short-term administration in acute gouty arthritis and ankylosing spondylitis
Diagnostic testing of adrenocortical hyperfunction
Treatment for trichinosis with neurologic or myocardial involvement

Pharmacology

Decreases inflammation by inhibiting the migration of leukocytes and reversal of increased capillary permeability, suppresses normal immune response

Dosage & Administration

Oral dosages in adults from 1 mg to 10 mg
Oral dosages in children from 0.03-0.20 mg/kg body weight
Intravenous, intramuscular, or local injection administration
Use of infusion fluids like Sodium chloride 0.9%, Anhydrous glucose 5%, Invert sugar 10%, Sorbitol 5%, Ringer's solution
Doses of 0.05-0.20 mg/kg body weight for systemic therapy in adults
Recommended local therapy doses for intra-articular, intrabursal, and tendon sheath injections

Interaction

Enhanced potassium loss with diuretics and/or cardiac glycosides
Potential impairment of glucose tolerance with antidiabetics
Increased incidence and/or severity of gastrointestinal ulceration with non-steroidal anti-inflammatory drugs
Alteration of the need for oral anti-coagulants
Decreased effectiveness when used concomitantly with liver enzyme inducing drugs
Potential reduction in glucocorticoid dosage caution with concomitant use of salicylates
Impairment of gastrointestinal absorption when used concomitantly with antacids

Contraindications

Gastric and duodenal ulcers
Systemic and ophthalmic fungal infections
Viral infections like varicella and herpes genitalis infections
Glaucoma
Hypersensitivity to corticosteroids

Side Effects

Cushing-like syndrome
Fluid and electrolyte disturbances
Musculo-skeletal effects like myopathy and osteoporosis
Gastro-intestinal effects including ulceration and perforation
Dermatological effects like impaired wound healing and skin atrophy
Central nervous system effects such as psychic disturbances and convulsions
Immunosuppressive effects leading to increased susceptibility to infections

Pregnancy & Lactation

Pregnancy Category C, should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Glucocorticoids appear in breast milk, mothers taking high dosages should be advised not to breast-feed.

Precautions & Warnings

Use the lowest possible dose to control the condition under treatment
Use with caution in patients with congestive heart failure, hypertension, or renal insufficiency
Minimize drug-induced secondary adrenocortical insufficiency by gradual reduction of dosage
Use with caution in active or latent peptic ulcers, diverticulitis, and nonspecific ulcerative colitis
Special consideration for patients at increased risk of osteoporosis before initiating corticosteroid therapy
Observe for acute myopathy with high doses, especially in patients receiving concomitant therapy with neuromuscular blocking drugs

Use in Special Populations

To minimize potential growth effects, pediatric patients should be titrated to the lowest effective dose