Pradom 10 mg (Tablet)
Unit Price: ৳ 2.00 (10 x 10: ৳ 200.00)
Strip Price: ৳ 20.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Domperidone maleate |
| Company | Pristine pharmaceuticals ltd |
Title
- Pradom 10 mg Tablet
Categories
- Medicine
- Dopamine Antagonist
- Prokinetic Drug
Description
- Dyspeptic symptom complex
- Delayed gastric emptying
- Gastroesophageal reflux
- Esophagitis
- Acute nausea and vomiting
- Parkinson's disease
- Radiological studies
- Pharmacology
- Dosage & Administration
- Interaction
- Contraindications
- Side Effects
- Pregnancy & Lactation
- Precautions & Warnings
- Use in Special Populations
- Overdose Effects
- Therapeutic Class
- Storage Conditions
- Chemical Structure
- Common Questions about Pradom 10 mg Tablet
Attributes
- Dosage Form: Tablet
- Dosage Strength: 10 mg
- Indications:
- Epigastric sense of fullness
- Feeling of abdominal distension
- Upper abdominal pain
- Eructation
- Flatulence
- Early satiety
- Nausea and vomiting
- Heartburn
- Regurgitations of gastric contents in the mouth
- Non-ulcer dyspepsia
- Acute nausea and vomiting of various origins
- Nausea and vomiting induced by radiotherapy or drug therapy or in migraine
- Speeding barium transit in follow-through radiological studies
- Pharmacological Action:
- Dopamine antagonist
- Gastroprokinetic
- Blocks dopamine receptors in Chemoreceptor Trigger Zone and stomach
- Restores normal motility and tone of the upper gastrointestinal tract
- Facilitates gastric emptying
- Enhances antral and duodenal peristalsis
- Regulates contraction of the pylorus
- Increases esophageal peristalsis
- Regulates lower esophageal sphincter pressure
- Usual Adult Dose: 10-20 mg (1-2 tablets or 10-20 ml suspension) every 6-8 hours daily, maximum 80 mg daily
- Usual Children Dose: 2-4 ml suspension/10 kg body weight or 0.4-0.8 ml pediatric drops/10 kg body weight every 6-8 hours daily
- Route of Administration: Oral, rectal in suppositories
- Interaction:
- Anticholinergic drugs may antagonize the antidyspeptic effect
- Antacids and antisecretory drugs lower its oral bioavailability
- Metabolized through CYP3A4 pathway, may be affected by inhibitors
- No influence on neuroleptics
- Suppression of unwanted peripheral effects of dopaminergic agonists
- Contraindications:
- Known hypersensitivity
- Neonates
- Gastrointestinal bleeding
- Mechanical obstruction or perforation
- Prolactinoma
- Side Effects:
- Transient intestinal cramps
- Rare extrapyramidal phenomena in children and adults
- Potential increase in plasma prolactin level
- Rare allergic reactions like rash and urticaria
- Pregnancy & Lactation:
- Use in the first trimester justified by therapeutic benefit
- No evidence of increased risk of malformations in humans
- Excretion in breast milk, lower concentration than plasma
- Precautions & Warnings:
- Caution in children due to risk of extra-pyramidal reactions
- Caution in hepatic impairment
- Special Populations:
- Use in infants with caution under medical supervision
- Caution in hepatic impairment
- Dose adjustment in severe renal insufficiency
- Overdose Effects:
- Drowsiness
- Disorientation
- Extrapyramidal reactions
- Activated charcoal administration recommended
- Therapeutic Class: Motility Stimulants
- Storage Conditions:
- Store below 30°C
- Protected from light & moisture
- Keep out of children's reach
- Chemical Structure:
- Molecular Formula: C22H24ClN5O2
- Chemical Structure Image: https://medex.com.bd/storage/res/g-res-380-domperidone-maleate-chemical-structure-4Q6P0Z8laWrV7xnOkSMm.svg
- Common Questions:
- Usage for nausea and vomiting
- Relief for nausea, vomiting, and indigestion
- Possible dizziness and sleepiness
- Avoidance of alcohol consumption
- Management of dry mouth
- Consultation for prolonged use