Fluxagal 150 mg (Capsule)
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Pristine pharmaceuticals ltd |
| Also available as |
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- Kerion
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections and cryptococcal infections (including meningitis)
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis and Cryptococcal infection
- Superficial Candidiasis
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis
Pharmacology
Fluconazole is a triazole antifungal agent. It is a potent inhibitor of fungal cytochrome P-450 dependent enzymes. Cytochrome P-450 enzyme system is an essential component of the fungal cell membrane responsible for the synthesis of ergosterol.
Dosage & Administration
- Adults:
- Vaginal Candidiasis: 150 mg as a single dose
- Oropharyngeal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14 days
- Oesophageal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14-30 days
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea: 150 mg weekly for 4-6 weeks
- Kerion: 50 mg daily for 20 days
- Pityriasis versicolor: 400 mg as a single dose
- Onychomycosis: 150 mg weekly for 12 months
- Invasive candidal infections and cryptococcal infections (including meningitis): Orally or by IV infusion, 400 mg on first day then 200-400 mg daily
- Prevention of cryptococcal meningitis: Orally or by IV infusion 200 mg daily
- Prevention of fungal infections in immunocompromised patients: Orally or by IV infusion, 50-400 mg daily
- Use in Specific Population:
- Elderly patient: The normal dose should be used if there is no evidence of renal impairment.
- Renal Impairment: Dosage intervals should be modified based on creatinine clearance
Interaction
Fluconazole has interactions with other medications such as warfarin, oral sulphonylureas, hydrochlorothiazide, phenytoin, rifampicin, combined oral contraceptives, cyclosporin, theophylline, and food, cimetidine, antacids, total body irradiation for bone marrow transplantation.
Contraindications
Fluconazole should not be used in patients with known hypersensitivity to Fluconazole or to related triazole compounds.
Side Effects
Common side effects include symptoms associated with the gastrointestinal tract, nausea, abdominal discomfort, diarrhea, and flatulence. Other adverse events such as rash are rarely encountered (Incidence less than 1%). Anaphylaxis has been reported in rare cases.
Pregnancy & Lactation
Fluconazole adverse fetal effects have been seen in animals only at dose levels associated with maternal toxicity. Its use in pregnancy or in women of childbearing potential is not recommended unless adequate contraception is employed.
Precautions & Warnings
- Abnormalities of Hepatic, Renal, Haematological and Other Biochemical Function Tests: Observed in some patients, particularly those with serious underlying diseases such as AIDS and cancer.
- Liver Enzymes Rise: Risk-benefit ratio of continued fuconazole treatment should be assessed in those patients in whom a significant rise of liver enzymes occurs.
- Exfoliative Cutaneous Reactions: Rarely encountered; should be monitored closely especially in AIDS patients.
- Lactation: Use in nursing mothers is not recommended.
Use in Special Populations
- Elderly: The normal dose should be used if there is no evidence of renal impairment.
- Renal Impairment: Dosage intervals or daily dosage should be modified based on creatinine clearance
Overdose Effects
In the event of overdosage, supportive measures and symptomatic treatment with gastric lavage if necessary may be adequate.