Seclotil 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Omeprazole
Company Pristine pharmaceuticals ltd
Also available as

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of the antisecretory effect within one hour
  • Maximum effect occurs within two hours
  • Inhibition of secretion lasts up to 72 hours

Dosage

  • 20 mg once daily for benign gastric and duodenal ulcer for 4-8 weeks
  • 40 mg daily for severe or recurrent cases of benign gastric and duodenal ulcer
  • 20 mg once daily for NSAID-associated duodenal or gastric ulcer for 4-8 weeks
  • 20 mg once daily for gastro-esophageal reflux disease for 4-8 weeks
  • 40 mg once daily for severe or refractory gastro-esophageal reflux disease
  • 10-20 mg daily for long-term management of acid reflux disease
  • 10-20 mg once daily for acid-related dyspepsia for 2-4 weeks
  • 40 mg once before surgery for prophylaxis of acid aspiration
  • Initial 60 mg once daily for Zollinger-Ellison syndrome
  • 20 mg twice daily in association with antimicrobial agents for Helicobacter pylori eradication regimen in peptic ulcer disease
  • 10-40 mg once daily for severe ulcerating reflux esophagitis in children over 1 year
  • 40 mg for prophylaxis of acid aspiration via IV injection
  • 40 mg once daily for duodenal ulcer, gastric ulcer or reflux esophagitis via IV injection
  • 60 mg daily for Zollinger-Ellison syndrome via IV injection

Administration

  • Intravenous administration only for Omeprazole IV injection
  • Slow intravenous injection for Omeprazole IV injection
  • Intravenous infusion over a period of 20-30 minutes or more for Omeprazole IV infusion
  • Dissolve in saline for infusion or 5% Dextrose for infusion
  • Reconstituted solution should not be mixed or co-administered with any other drug

Interaction

  • Reduced absorption of ketoconazole during Seclotil treatment
  • Metabolized in the liver through cytochrome P450
  • Potential to delay elimination of diazepam, phenytoin, and warfarin
  • Plasma concentrations of Seclotil and clarithromycin are increased during concomitant administration
  • No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxycillin or antacids
  • No evidence of interaction with piroxicam, diclofenac, or naproxen
  • Simultaneous treatment with Seclotil can lead to a 10% increase in the bioavailability of digoxin

Contraindications

  • Known hypersensitivity to Omeprazole
  • Suspected gastric ulcer with possible malignancy

Side Effects

  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, and erythema multiforme
  • Diarrhea, headache, constipation, nausea/vomiting, flatulence, and abdominal pain
  • Dry mouth, stomatitis, and candidiasis
  • Paraesthesia, dizziness, light headedness, and feeling faint
  • Somnolence, insomnia, and vertigo
  • Reversible mental confusion, agitation, depression, and hallucinations
  • Arthritic and myalgic symptoms
  • Blurred vision, taste disturbance, peripheral edema, increased sweating, gynaecomastia, leucopenia, thrombocytopenia, agranulocytosis, pancytopenia, and anaphylactic shock
  • Malaise, fever, bronchospasm, encephalopathy in patients with pre-existing severe liver disease, hepatitis, interstitial nephritis, hepatic failure, and increases in liver enzymes

Pregnancy & Lactation

  • No adverse effects of Omeprazole on pregnancy or fetus/newborn child
  • Omeprazole can be used during pregnancy
  • No information available on the passage of Omeprazole into breast milk or its effects on the neonate
  • Breastfeeding should be discontinued if Omeprazole use is essential
  • Safety and effectiveness not established in pediatric patients less than 18 years of age

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and Seclotil
  • Possible association with an increased risk for osteoporosis-related fractures
  • Noted atrophic gastritis in patients treated long-term with Seclotil
  • Concomitant use with methotrexate may lead to methotrexate toxicities

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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