Seclotil 40 mg (Capsule (Enteric Coated))
Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Pristine pharmaceuticals ltd |
Also available as |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of the antisecretory effect within one hour
- Maximum effect occurs within two hours
- Inhibition of secretion lasts up to 72 hours
Dosage
- 20 mg once daily for benign gastric and duodenal ulcer for 4-8 weeks
- 40 mg daily for severe or recurrent cases of benign gastric and duodenal ulcer
- 20 mg once daily for NSAID-associated duodenal or gastric ulcer for 4-8 weeks
- 20 mg once daily for gastro-esophageal reflux disease for 4-8 weeks
- 40 mg once daily for severe or refractory gastro-esophageal reflux disease
- 10-20 mg daily for long-term management of acid reflux disease
- 10-20 mg once daily for acid-related dyspepsia for 2-4 weeks
- 40 mg once before surgery for prophylaxis of acid aspiration
- Initial 60 mg once daily for Zollinger-Ellison syndrome
- 20 mg twice daily in association with antimicrobial agents for Helicobacter pylori eradication regimen in peptic ulcer disease
- 10-40 mg once daily for severe ulcerating reflux esophagitis in children over 1 year
- 40 mg for prophylaxis of acid aspiration via IV injection
- 40 mg once daily for duodenal ulcer, gastric ulcer or reflux esophagitis via IV injection
- 60 mg daily for Zollinger-Ellison syndrome via IV injection
Administration
- Intravenous administration only for Omeprazole IV injection
- Slow intravenous injection for Omeprazole IV injection
- Intravenous infusion over a period of 20-30 minutes or more for Omeprazole IV infusion
- Dissolve in saline for infusion or 5% Dextrose for infusion
- Reconstituted solution should not be mixed or co-administered with any other drug
Interaction
- Reduced absorption of ketoconazole during Seclotil treatment
- Metabolized in the liver through cytochrome P450
- Potential to delay elimination of diazepam, phenytoin, and warfarin
- Plasma concentrations of Seclotil and clarithromycin are increased during concomitant administration
- No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxycillin or antacids
- No evidence of interaction with piroxicam, diclofenac, or naproxen
- Simultaneous treatment with Seclotil can lead to a 10% increase in the bioavailability of digoxin
Contraindications
- Known hypersensitivity to Omeprazole
- Suspected gastric ulcer with possible malignancy
Side Effects
- Skin rash, urticaria, and pruritus
- Photosensitivity, bullous eruption, and erythema multiforme
- Diarrhea, headache, constipation, nausea/vomiting, flatulence, and abdominal pain
- Dry mouth, stomatitis, and candidiasis
- Paraesthesia, dizziness, light headedness, and feeling faint
- Somnolence, insomnia, and vertigo
- Reversible mental confusion, agitation, depression, and hallucinations
- Arthritic and myalgic symptoms
- Blurred vision, taste disturbance, peripheral edema, increased sweating, gynaecomastia, leucopenia, thrombocytopenia, agranulocytosis, pancytopenia, and anaphylactic shock
- Malaise, fever, bronchospasm, encephalopathy in patients with pre-existing severe liver disease, hepatitis, interstitial nephritis, hepatic failure, and increases in liver enzymes
Pregnancy & Lactation
- No adverse effects of Omeprazole on pregnancy or fetus/newborn child
- Omeprazole can be used during pregnancy
- No information available on the passage of Omeprazole into breast milk or its effects on the neonate
- Breastfeeding should be discontinued if Omeprazole use is essential
- Safety and effectiveness not established in pediatric patients less than 18 years of age
Precautions & Warnings
- Avoid concomitant use of clopidogrel and Seclotil
- Possible association with an increased risk for osteoporosis-related fractures
- Noted atrophic gastritis in patients treated long-term with Seclotil
- Concomitant use with methotrexate may lead to methotrexate toxicities
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
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