Naproqure Plus 500 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Naproxen sodium esomeprazole magnesium
Company Pristine pharmaceuticals ltd

Indications

  • Relief of signs and symptoms of osteoarthritis
  • Relief of signs and symptoms of rheumatoid arthritis
  • Relief of signs and symptoms of ankylosing spondylitis
  • Decrease the risk of developing gastric ulcers in patients at risk of NSAID-associated gastric ulcers

Pharmacology

  • Immediate release Esomeprazole Magnesium layer
  • Enteric-coated Naproxen core
  • Inhibition of prostaglandin synthesis by Naproxen
  • Suppression of gastric acid secretion by Esomeprazole

Dosage

  • Use lowest effective dose
  • Adult dosage: 375 mg naproxen/20 mg of esomeprazole or 500 mg naproxen/20 mg of esomeprazole twice daily
  • Adolescent patient dosage: 375 mg naproxen/20 mg of esomeprazole or 500 mg naproxen/20 mg of esomeprazole

Administration

  • Tablet should not be split, chewed, crushed or dissolved
  • To be taken at least 30 minutes before meals

Interaction

  • Concomitant use of NSAIDs with ACE inhibitors, diuretics & beta-blockers
  • Concomitant use with warfarin
  • Inhibition of gastric acid secretion by Esomeprazole affecting drug absorption
  • Effect of high-fat food on absorption of Naproxen & Esomeprazole

Contraindications

  • Known hypersensitivity to any component of the tablet or substituted benzimidazoles
  • History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
  • Peri-operative use in the setting of coronary artery bypass graft (CABG) surgery

Side Effects

  • Decrease in incidence of gastrointestinal side effects from Naproxen
  • Decrease in occurrence of gastric ulcers and NSAID associated upper gastrointestinal adverse events compared to Naproxen alone
  • Potential risk of arterial thrombotic events associated with high doses and long-term use of NSAIDs
  • Adverse events such as oedema, hypertension, and cardiac failure reported in association with NSAID treatment

Pregnancy & Lactation

  • Use not recommended during first and second trimester of pregnancy
  • Use contraindicated during the third trimester of pregnancy
  • Unknown excretion of esomeprazole in human milk
  • NSAID use may impair female fertility

Precautions & Warnings

  • Avoid the combination of Naproxen with other NSAIDs
  • Minimize undesirable effects by using lowest effective dose for shortest duration
  • Increased risk of adverse events in older people
  • Potential impact on vitamin absorption and gastrointestinal infections with long-term use of proton pump inhibitors

Use in Special Populations

  • Increased unbound plasma fraction of naproxen in elderly patients
  • Not recommended for use in patients with moderate to severe renal impairment
  • Close monitoring and possible dose reduction in patients with mild to moderate hepatic impairment

Overdose Effects

  • Symptoms of Naproxen overdose
  • Symptoms of esomeprazole overdose
  • Management of Naproxen overdose
  • Management of esomeprazole overdose

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store below 30°C
  • Protect from light and moisture
  • Keep out of reach of children

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