Prebalin CR 82.5 mg (Tablet (Extended Release))

Title

• Prebalin CR 82.5 mg XR Tablet

Categories

• Anticonvulsant
• Pain Management
• Neuropathic Pain
• Seizure Control
• Fibromyalgia Management

Description

• Prebalin CR 82.5 mg XR Tablet is indicated for various conditions including neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, fibromyalgia, and adjunctive therapy for the treatment of partial-onset seizures.

Indications

• Neuropathic pain associated with diabetic peripheral neuropathy (DPN)
• Postherpetic neuralgia (PHN)
• Adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older
• Fibromyalgia
• Neuropathic pain associated with spinal cord injury

Pharmacology

• Structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)
• Binds with high affinity to the alpha2-delta site in central nervous system tissues
• Mechanism of action not fully elucidated

Dosage

• Maximum recommended dose of Pregabalin is 100 mg three times a day for DPN in at least 60 ml/min creatinine clearance
• Begin dosing of Pregabalin CR at 165 mg once daily and increase to 330 mg once daily within 1 week
• Recommended dose of Pregabalin is 75 to 150 mg two times a day or 50 to 100 mg three times a day for PHN
• Recommended dose of Pregabalin is 300 to 450 mg/day for fibromyalgia
• Recommended dose range of Pregabalin is 150 to 600 mg/day for spinal cord injury

Administration

• Taken orally with or without food
• Pregabalin CR tablet should be administered after an evening meal
• Swallowed whole and should not be split, crushed or chewed
• Gradually tapered over a minimum of 1 week when discontinuing both Pregabalin and Pregabalin CR

Interaction

• Unlikely to be involved in significant pharmacokinetic drug interactions
• No significant drug interaction with food and others

Contraindications

• Contraindicated in patients with known hypersensitivity to Pregabalin or any of its components

Side Effects

• Most common side effects in adults include dizziness, somnolence, dry mouth, edema, blurred vision, weight gain, and thinking abnormal (difficulty with concentration/attention)
• Most common side effects in pediatric patients for the treatment of partial onset seizures are increased weight and increased appetite

Pregnancy & Lactation

• No adequate and well-controlled studies with pregabalin in pregnant women
• Small amounts of pregabalin detected in the milk of lactating women
• Breastfeeding not recommended during treatment with pregabalin due to potential risk of tumorigenicity

Precautions & Warnings

• Angioedema and hypersensitivity reactions may occur
• Increased risk of suicidal thoughts or behavior
• Respiratory depression may occur when used with concomitant CNS depressants or in the setting of underlying respiratory impairment
• May cause dizziness, somnolence, and impair patient’s ability to drive or operate machinery
• Increased seizure frequency or other adverse reactions may occur if rapidly discontinued
• Caution should be exercised when coadministering with thiazolidinedione antidiabetic agents

Use in Special Populations

• Safety and effectiveness in pediatric patients not established for various indications
• Safety and effectiveness of Prebalin CR extended-release tablet not established in pediatric patients
• Safety and effectiveness not established in pediatric patients below the age of 1 month for adjunctive therapy for partial onset seizures

Overdose Effects

• Signs and symptoms include reduced consciousness, depression/anxiety, confusional state, agitation, restlessness, seizures, and heart block
• No specific antidote
• General supportive care of the patient is indicated

Therapeutic Class

• Adjunct anti-epileptic drugs
• Primary anti-epileptic drugs

Storage Conditions

• Keep in a cool & dry place (below 30°C), protected from light & moisture
• Keep out of the reach of children

Chemical Structure

• Molecular Formula: C8H17NO2

Common Questions about Prebalin CR 82.5 mg Tablet

• First-line treatment for neurotic pain, shingles, seizures, and fibromyalgia
• To be taken till improvement in health conditions
• Should be taken after food in a prescribed dosage
• Instructions for storage and disposal
• Works differently for different diseases
• Duration depends on the condition
• Do not stop suddenly without consulting a doctor
• Can be used with Diazepam
• May cause weight gain
• Quick Tips for usage

Image

• https://medex.com.bd/storage/res/g-res-919-pregabalin-chemical-structure-dKjKzfuVRrNkwNMBalNK.svg

Related Brands

• Prelica CR 165 mg (Tablet (Controlled Release)) - radiant-pharmaceuticals-ltd
• Prelica CR 82.5 mg (Tablet (Controlled Release)) - radiant-pharmaceuticals-ltd
• Prelica 150 mg (Capsule) - radiant-pharmaceuticals-ltd
• Neurolin CR 165 mg (Tablet (Controlled Release)) - square-pharmaceuticals-plc
• Xil-CR 82.5 mg (Tablet (Controlled Release)) - orion-pharma-ltd