Triforce 500 mg/vial (IM Injection)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Social marketing company |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It interferes with the synthesis of the bacterial cell wall and has a high degree of stability in the presence of beta lactamases. Ceftriaxone has a relatively long plasma elimination half-life of about 6 to 9 hours and is highly protein bound (95%).
Dosage
- Adult: 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
- Children: 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
- Duration of therapy: 4 to 14 days; longer in complicated infections
Administration
- Intramuscular Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Lidocaine HCI 1% injection
- Intravenous Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Water for injection
- Injection should be administered over 2-4 minutes or by tubing infusion over a period of 30 minutes
Interaction
No drug interactions reported
Contraindications
Not to be given to patients with a history of hypersensitivity to cephalosporin antibiotics
Side Effects
- Gastro-intestinal effects
- Cutaneous reactions
- Hematologic reactions
- Hepatic reactions
- CNS reactions
- Local phlebitis following IV administration
Pregnancy & Lactation
Safety in human pregnancy not established. Caution advised during lactation.
Precautions & Warnings
- Anaphylactic shock
- Sonograms of the gallbladder
- Blood picture should be checked during prolonged treatment
Use in Special Populations
Must not be given to premature and newborn neonates
Overdose Effects
No specific antidote. Treatment should be symptomatic
Therapeutic Class
Third generation Cephalosporins
Storage Conditions
Store in a cool, dry place below 30°C, away from light & moisture. Keep out of the reach of children