Doltro 60 mg/2 ml (IM/IV Injection)

2 ml ampoule: ৳ 100.00

Medicine Details

Indications

  • Short-term management of moderate to severe acute post-operative pain
  • Relieves pain, inflammation, and light sensitivity after ocular surgery
  • Decreases eye inflammation or redness caused by seasonal allergies

Description

  • Belongs to the pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drug (NSAID)
  • Chemical name: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • Inhibits synthesis of prostaglandins
  • Associated with the S-form
  • Highly protein bound
  • Metabolized in the liver
  • Products of metabolism and some unchanged drugs are excreted in the urine

Pharmacology

  • Acts by inhibiting the cyclooxygenase enzyme system
  • Minimal anti-inflammatory effect at analgesic dose

Dosage & Administration

  • Tablet: Recommended dose is 10 mg every 4-6 hours for short-term use (up to 7 days)
  • Recommended dosage for injection based on age, weight, and condition
  • Eye Drops: Adults - 1 drop in each eye 4 times daily

Interaction

  • Other NSAIDs or aspirin increase the side effects
  • Anti-coagulants enhance anti-coagulant effect
  • Beta Blocker reduces the anti-hypertensive effect
  • ACE Inhibitors increase the risk of renal impairment
  • Methotrexate enhances the toxicity of methotrexate

Contraindications

  • Hypersensitivity to Ketorolac or other NSAIDs
  • Not recommended for children under 16 years of age
  • Contraindicated as a prophylactic analgesic before surgery

Side Effects

  • Nausea
  • Vomiting
  • Gastro-intestinal bleeding
  • Melana
  • Peptic ulcer
  • Pancreatitis
  • Anxiety
  • Drowsiness
  • Headache
  • Excessive thirst
  • Fatigue
  • Bradycardia
  • Hypertension
  • Palpitation
  • Chest pain
  • Infertility in females
  • Pulmonary edema

Pregnancy & Lactation

  • US FDA Pregnancy category: C
  • Should be avoided in pregnancy and lactation unless benefits outweigh risks

Precautions & Warnings

  • Caution in patients over 65 years
  • Caution in patients with active or suspected peptic ulcer
  • Caution in patients with gastrointestinal bleeding or asthma
  • Caution in patients with liver dysfunction
  • Discontinue use of topical NSAIDs in patients with evidence of corneal epithelial breakdown
  • Avoid administering while wearing contact lenses

Therapeutic Class

  • Drugs used for Rheumatoid Arthritis
  • Non-Opioid Analgesics

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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