Ketocid 600 mg (Tablet)
Unit Price: ৳ 40.00 (6 x 10: ৳ 2,400.00)
Strip Price: ৳ 400.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Amino acid ketoanalogues |
| Company | Unimed unihealth pharmaceuticals ltd |
Title and Categories
- Ketocid Amino Acid Keto Analogues Tablets
- Genito-urinary Preparations
Description
- A nutritional supplement for prevention and treatment of damages due to faulty or deficient protein metabolism in chronic kidney disease
- Contains essential amino acids and their corresponding keto analogues
- Dosage applies to adults with 70 kg body weight
- Should be taken with limited dietary protein intake 40 gm/day or less
Composition
- Ingredients:
- Calcium-3-methyl-2-oxo-valerate (α-ketoanalogue of isoleucine, calcium-salt): 67 mg
- Calcium-4-methyl-2-oxo-valerate (α-ketoanalogue of leucine, calcium-salt): 101 mg
- Calcium-2-oxo-3-phenylpropionate (α-ketoanalogue of phenylalanine, calcium-salt): 68 mg
- Calcium-3-methyl-2-oxobutyrate (α-ketoanalogue of valine, calcium salt): 86 mg
- Calcium-DL-2-hydroxy-4-(methylthio) butyrate (α-hydroxyanalogue to methionine, calcium-salt): 59 mg
- L-lysine acetate USP (eqv. to Lysine 75mg) :105 mg
- L-threonine USP: 53 mg
- L-tryptophan USP: 23 mg
- L-histidine USP as Histidine Hydrochloride Monohydrate: 38 mg
- L-tyrosine USP: 30 mg
Indications
- Prevention and treatment of damages due to faulty or deficient protein metabolism in chronic kidney disease
- For patients with glomerular filtration rate (GFR) less than 25 ml/min
- In connection with limited dietary protein intake 40 gm/day or less (adult)
Mode of Action
- Improves the metabolism of protein in the body
- Facilitates intake of essential amino acids while minimizing amino-nitrogen intake
- Transaminates keto- and hydroxy-analogues to essential amino acids
Dosage and Administration
- 4-8 tablets 3 times a day during meals for adults (with 70 kg body weight)
- Swallow whole, do not chew
- Ingest with meals containing 40 g/day protein or less (adults)
- Given as long as GFR is between 5 and about 25mL/minute
Precautions and Warnings
- Regular monitoring of serum calcium level required
- Ensure sufficient calorie intake
- Contains phenylalanine, so caution needed in the presence of hereditary phenylketonuria
Interaction
- Concomitant administration of calcium-containing drugs may cause or aggravate elevated serum calcium levels
- Ketocid dose may need reduction with aluminum hydroxide administration
- Need at least two hours interval between the ingestion of Alpha ketoanalogue and certain drugs (e.g., tetracyclines, quinolones, iron, fluoride, estramustine)
- Risk of increased susceptibility to cardioactive glycosides, and hence the risk for arrhythmia with Alpha ketoanalogue
Contraindications
- Hypersensitivity to the active substances or excipients
- Hypercalcemia
- Disturbed amino acid metabolism
Side Effects
- Hypercalcaemia (Very Rare) - may require reduction in vitamin D and Ketocid intake if persisting
Pregnancy and Lactation
- Caution advised in pregnancy due to inadequate data
- No experience so far with use during lactation
Therapeutic Class
- Other genito-urinary preparations
Storage Conditions
Store at a temperature not exceeding 30°C in a dry place. Protect from light & moisture