Befree 5 mg/5 ml (Oral Solution)
100 ml bottle: ৳ 150.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Sodium picosulfate |
| Company | Medicon pharmaceuticals ltd |
| Also available as |
Indications
- Constipation of any etiology
- Relief from prolonged & recurrent constipation
- Bowel clearance before surgery, childbirth or radiological investigations.
Pharmacology
- Sodium Picosulfate is a triarylmethane group derivative stimulant laxative. After oral administration it is activated by the colonic bacteria and acts locally in the colon. The active form then stimulates the nerve endings of the intestinal wall and results in colonic peristalsis with promotion of accumulation of water and electrolytes in the colonic lumen. This results in stimulation of defecation, reduction of transit time and softening of the stool. Stimulation of the rectum causes increased motility and a feeling of rectal fullness. The rectal effect may help to restore the "call to stool".
Dosage & Administration
- For oral administration. The following dosages are recommended to be taken at night to produce evacuation the following morning. It is recommended to start with the lowest dose. The dose may be adjusted up to the maximum recommended dose to produce regular stools. The maximum recommended daily dose should not be exceeded:
- 10 mg tablet dose: Adults and children over 10 years of age: 5-10 mg per day. Children aged 4-10 years: 2.5-5 mg per day.
- Oral Solution (5 mg/5 ml) dose: Adults and children over 10 years of age: 5-10 ml or one to two teaspoonful per day. Children aged 4-10 years: 2.5-5 ml or half to one teaspoonful per day. Children from 1 month to 4 years of age: 0.25 ml/kg body weight per day.
- Concentrated Oral Solution (7.5 mg/ml) dose: Adults and children over 10 years of age: 0.67-1.33 ml per day. Children aged 4-10 years: 0.33-0.67 ml per day.
Interaction
- The concomitant use of diuretics or adreno-corticosteroids may increase the risk of electrolyte imbalance if excessive doses are taken. Concurrent administration of antibiotics may reduce the laxative action of Befree.
Contraindications
- Ileus or intestinal obstruction
- severe painful and/or feverish acute abdominal conditions (e.g. appendicitis) potentially associated with nausea and vomiting
- acute inflammatory bowel diseases
- severe dehydration
- known hypersensitivity to Sodium Picosulfate or any other component of the product.
Side Effects
- Hypersensitivity
- dizziness
- syncope
- vasovagal response
- gastrointestinal disorders
- diarrhea
- abdominal pain and abdominal cramps
- nausea
- vomiting
Pregnancy & Lactation
- There are no reports of undesirable or damaging effects during pregnancy or to the foetus attributable to the use of this product. Use of the drug should be avoided during the first trimester. Clinical data show that neither the active moiety of sodium Picosulfate (BHPM or bis-(p hydroxyphenyl)-pyridyl-2-methane) nor its glucuronides are excreted into the milk of healthy lactating females.
Precautions & Warnings
- Prolonged excessive use may lead to fluid and electrolyte imbalance and hypokalemia
- Harmful for those suffering from alcoholism
- To be taken into account in pregnant or breast-feeding women, children and high-risk groups such as patients with liver disease or epilepsy.
Overdose Effects
- Laxatives when taken in chronic overdosage may cause chronic diarrhea
- abdominal pain
- hypokalemia
- secondary hyperaldosteronism
- renal calculi
- Renal tubular damage
- metabolic alkalosis
- muscle weakness secondary to hypokalemia have also been described in association with chronic laxative abuse.
Therapeutic Class
- Stimulant Laxative
Storage Conditions
- Keep below 30°C temperature, away from light & moisture
- Keep out of the reach of children.
Chemical Structure
- Molecular Formula : C18H15NNa2O9S2
Common Questions about Befree 5 mg/5 ml Oral Solution
- Befree 5 mg/5 ml Solution belongs to the class of laxatives.
- Befree 5 mg/5 ml Solution is used in the treatment of constipation.
- Befree 5 mg/5 ml Solution is to be taken till the time you see an improvement in your health conditions.
- Befree 5 mg/5 ml Solution should be taken in the dosage as prescribed by the doctor.
- Befree 5 mg/5 ml Solution should be taken at bed-time as it requires 6-8 hours to show effect.
- Befree 5 mg/5 ml Solution should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.
- Befree 5 mg/5 ml Solution is not prescribed to pregnant women unless necessary. Consult your doctor beforehand.
- Breastfeeding women are not suggested to take Befree 5 mg/5 ml Solution unless necessary. Consult your doctor beforehand.
- No case of addiction has been reported yet.
- Take Befree 5 mg/5 ml Solution as soon as you remember. However, stick to your routine if it's the time for the next dose. Do not double the dose.
- Together with Befree 5 mg/5 ml Solution, taking a fiber-rich diet containing whole grain bread and cereals, bran, fruits and green leafy vegetables, is essential to maintain healthy bowel function.
- Avoid taking a Befree 5 mg/5 ml Solution for more than 1 week, unless prescribed by the doctor, as it leads to dependency on the laxative action to produce a bowel movement.
- Take Befree 5 mg/5 ml Solution after 2 hours from other medicines, as it may interfere with the absorption of other medicines.
- Befree 5 mg/5 ml Solution should be preferably taken at bedtime because it requires 6 to 8 hours to show impact.