Eporise 3000 IU (IV/SC Injection)
3000 IU pre-filled syringe: ৳ 1,400.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Erythropoietin alfa |
| Company | Ziska pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of anemia in Chronic Kidney Disease (CKD) patients on dialysis
- Treatment of anemia in Chronic Kidney Disease (CKD) patients not on dialysis
- Treatment of anemia in HIV-infected patients treated with Zidovudine
- Reduction of allogeneic RBC transfusions in patients undergoing elective noncardiac nonvascular surgery
- Prevention of anemia of prematurity in infants with specific birth weight and gestational age
Description
- Recombinant human erythropoietin (EPO)
- Expressed in Chinese hamster ovary cells
- 165 amino acid sequence identical to human urinary EPO
- Apparent molecular weight of about 30,400 daltons
Dosage
- Evaluation of iron stores and nutritional factors before treatment
- Monitor hemoglobin levels at least weekly until stable, then at least monthly
- Instructions for dose adjustments based on hemoglobin levels and patient response
- Specific starting doses and dose adjustments for different patient groups
Administration
- Preparation and administration guidelines
- Instructions to not shake or use frozen Erythropoietin alfa
- Visual inspection of parenteral drug products prior to administration
- Discard unused portions of Erythropoietin alfa
Interaction
- Potentiated effect of Eporise by simultaneous therapeutic administration of a haematinic agent
- Specifically mentioned ferrous sulphate as a haematinic agent
Contraindications
- Uncontrolled hypertension
- Serious allergic reactions to Erythropoietin alfa
- Patients who develop Pure Red Cell Aplasia (PRCA) following treatment with any erythropoietin
Side Effects
- Adverse reactions in 5% of Eporise treated patients in clinical studies
- Specific adverse reactions for patients with CKD, Zidovudine-treated HIV-infected patients, cancer patients on chemotherapy, surgery patients, and premature infants
Pregnancy & Lactation
- Lack of adequate and well-controlled studies in pregnant women
- Reproduction toxicology observed in animal studies
- Specific recommendations for chronic renal failure patients and pregnant or lactating surgical patients
- Caution advised for nursing women
Overdose Effects
- Wide therapeutic margin of Eporise
- Management of hemoglobin levels above desired level in case of overdosage
- Observation of severe hypertension following overdose with ESAs
Therapeutic Class
- Drugs for Haemolytic Hypoplastic & Renal Anemia
Storage Conditions
- Temperature range for storage
- Instructions to avoid freezing or shaking
- Recommendation to store in original package to protect from light