Tamsulin 0.4 mg (Capsule (Modified Release))

Indications

• Treatment of functional symptoms of Benign Prostatic Hyperplasia (BPH)

Pharmacology

• Selective alpha1 adrenoceptor blocking agent
• Relaxes smooth muscle in the bladder neck and prostate
• Improves urine flow rate
• Reduces symptoms of BPH
• Complete absorption (90%) under fasting conditions
• Time to maximum concentration (Tmax) reached by four to seven hours
• Extensively metabolized by cytochrome P 450 enzymes
• Elimination half-life ranges from five to fifteen hours

Dosage & Administration

• Tamsulosin Hydrochloride 0.4 mg (one capsule) daily, to be taken after meal at night
• Dose may be increased to 0.8 mg once daily after 2 to 4 weeks
• Capsule should be swallowed whole with a glass of water

Interaction

• Concurrent administration with other alfa1-adrenoceptor antagonists may lead to hypotensive effects
• No interactions seen with atenolol, enalapril, or nifedipine
• Cimetidine may increase plasma levels of Tamsulin
• Warfarin may increase the elimination rate of Tamsulin

Contraindications

• Hypersensitivity to Tamsulosin hydrochloride
• History of orthostatic hypotension
• Severe hepatic insufficiency
• Potential for reduction in blood pressure and syncope

Side Effects

• Dizziness
• Abnormal ejaculation
• Headache
• Asthenia
• Postural hypotension
• Palpitations

Pregnancy & Lactation

• Not recommended for use

Precautions & Warnings

• Transient postural symptoms may occur
• Use in patients with micturition syncope not advised
• Effects on ability to drive and use machines

Overdose Effects

• Acute hypotension likely to occur after overdosage
• Cardiovascular support should be given
• Renal function should be monitored
• General supportive measures applied

Therapeutic Class

• BPH/ Urinary retention/ Urinary incontinence

Storage Conditions

• Store in a cool and dry place below 30°C, protected from light

Related Brands

• Inturia 0.4 mg (Capsule (Modified Release)) - dbl-pharmaceuticals-ltd