Tamsulin Plus 0.4 mg+0.5 mg (Capsule)
Unit Price: ৳ 18.00 (5 x 4: ৳ 360.00)
Strip Price: ৳ 72.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tamsulosin hydrochloride dutasteride |
| Company | Team pharmaceuticals ltd |
Indications
- Treatment of moderate to severe symptoms of benign prostatic hyperplasia (BPH)
- Reduction in the risk of acute urinary retention and surgery in BPH patients
Pharmacology
- Tamsulosin Hydrochloride, an antagonist of alpha1A-adrenoreceptors
- Dutasteride, a dual 5 alpha reductase inhibitor (5ARI)
- Improvement in urine flow rate and reduction in BPH symptoms
- Affects dynamic component of BPH by inhibiting alpha1-adrenoreceptors
- Affects static component of BPH by inhibiting conversion of Testosterone to Dihydrotestosterone (DHT)
- Selective for alpha 1A and alpha 1D receptors over alpha1B-adrenoreceptor subtype
Dosage & Administration
- Recommended dose: Tamsulosin Hydrochloride 0.4 mg & Dutasteride 0.5 mg once daily
- Dosage adjustment for severe hepatic impairment
- Capsules should be swallowed whole and not chewed or opened
Interaction
- No drug interaction studies for Dutasteride-Tamsulosin combination
- Effects of other drugs on the pharmacokinetics of Dutasteride
- Effects of Dutasteride on the pharmacokinetics of other drugs
Contraindications
- Contra-indicated in women, children, patients with hypersensitivity to Dutasteride and Tamsulosin, soya, peanut or any excipients
- Contra-indicated in patients with a history of orthostatic hypotension and severe hepatic impairment
Side Effects
- Impotence
- Decreased libido
- Breast disorders
- Ejaculation disorders
- Dizziness
Pregnancy & Lactation
- Contra-indicated for use by women
- No studies on effects of combination on pregnancy, lactation and fertility
- Dutasteride reported to affect semen characteristics in healthy men
Precautions & Warnings
- Prescribed after careful benefit risk assessment
- Increased risk of adverse events including cardiac failure
- Effects on prostate specific antigen (PSA) and prostate cancer detection
- Regular evaluation for high grade prostate cancer
- Caution in renal impairment and hypotension
- Intraoperative Floppy Iris Syndrome observed during cataract surgery
Overdose Effects
- No data available for Tamsulosin-Dutasteride combination overdose
- Single daily doses of Dutasteride up to 40 mg/day administered without significant safety concerns
- Acute overdose with 5 mg Tamsulosin Hydrochloride reported
Therapeutic Class
- BPH/ Urinary retention/ Urinary incontinence
Storage Conditions
- Store in a cool and dry place, protected from light
Related Brands
- Prostacare-D 0.4 mg+0.5 mg (Capsule) - chemist-laboratories-ltd
- Duodart 0.4 mg+0.5 mg (Capsule) - nuvista-pharma-ltd
- Hi-Flow D 0.4 mg+0.5 mg (Capsule) - popular-pharmaceuticals-ltd
- Prosulin-D 0.4 mg+0.5 mg (Capsule) - euro-pharma-ltd
- Tamisol D 0.4 mg+0.5 mg (Capsule) - healthcare-pharmaceuticals-ltd