Ivacard 5 mg (Tablet)
Unit Price: ৳ 25.00 (2 x 10: ৳ 500.00)
Strip Price: ৳ 250.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ivabradine |
| Company | Aristopharma ltd |
| Also available as |
Indications
- Symptomatic treatment of chronic stable angina pectoris in coronary artery disease patients
- Patients unable to tolerate or with a contra-indication to the use of beta-blockers
- In combination with beta-blockers in inadequately controlled patients
Pharmacology
- Pure heart rate lowering agent
- Selective inhibition of the cardiac pacemaker I f current
- Regulation of heart rate
- Decreased cardiac workload and oxygen consumption
- Prolongs diastole for increased coronary artery perfusion
- No effect on intra-atrial, atrioventricular or intraventricular conduction times
- No effect on myocardial contractility or ventricular repolarization
Dosage & Administration
- Usual starting dose of 5 mg twice daily
- May be increased to 7.5 mg twice daily
- Dose adjusted downwards if heart rate decreases persistently below 50 bpm
- Lower starting dose for elderly patients
- No dose adjustment for renal insufficiency above 15ml/min
- Caution in patients with creatinine clearance below 15ml/min
- No dose adjustment for mild hepatic impairment
- Exercise caution in patients with moderate hepatic impairment
- Contra-indicated for use in severe hepatic insufficiency
- Not recommended for use in children and adolescents
Interaction
- Avoid concomitant use with QT wave prolonging medicinal products
- Close cardiac monitoring if combination appears necessary
Contraindications
- History of hypersensitivity
- Resting heart rate below 60 bpm
- Cardiogenic shock
- Acute myocardial infarction
- Severe hypotension
- Severe hepatic insufficiency
- Sick sinus syndrome
- Sino-atrial block
- Heart failure
- Pacemaker dependent
- Unstable angina
- 3rd degree AV block
- Combination with strong cytochrome P-450 3A4 inhibitors
Side Effects
- Visual symptoms
- Blurred vision
- Bradycardia
- 1st degree AV block
- Ventricular extrasystoles
- Headaches
- Dizziness
Pregnancy & Lactation
- Contra-indicated during pregnancy
- Excreted in milk, contra-indicated during breast-feeding
Precautions & Warnings
- Mild to moderate hypotension
- Atrial fibrillation
- Patients with congenital QT syndrome or treated with QT wave prolonging medicinal products
- Moderate hepatic insufficiency
- Severe renal insufficiency
Therapeutic Class
- Other Anti-anginal & Anti-ischaemic drugs
Storage Conditions
- Keep below 30°C temperature
- Keep away from light & moisture
- Keep out of the reach of children