Actifol 5 mg (Tablet)
Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Folinic acid |
| Company | Aci limited |
| Also available as |
Indications
- Neutralising the immediate toxic effects of folic acid antagonists, e.g. methotrexate
- Calcium folinate rescue - a treatment technique using calcium folinate in conjunction with folic acid antagonists, e.g. methotrexate, to minimize systemic toxicity
- The treatment of megaloblastic anaemias due to sprue, nutritional deficiency, pregnancy, infancy, liver disease and malabsorption syndrome
Composition
- Calcium Folinate Hydrate BP 6.249 mg equivalent to Folinic Acid 5 mg
- Calcium Folinate Hydrate BP 18.746 mg equivalent to Folinic Acid 15 mg
Pharmacology
- Calcium Folinate Hydrate is the calcium salt of folinic acid, a metabolite and active form of folic acid
- It is involved as a cofactor for 1-carbon transfer reactions in the biosynthesis of purine and pyrimidines of nucleic acids
- It is a potent antidote for both hematopoietic and reticuloendothelial toxic effects of folic acid antagonists
Dosage & Administration
- Calcium folinate rescue should begin as soon as possible after an inadvertent overdosage and within 24 hours of methotrexate administration
- There are no fixed guidelines regarding the dose of methotrexate that triggers an automatic subsequent Folinic Acid administration
- The recommended dose of Folinic Acid to counteract hematologic toxicity from folic acid antagonists with less affinity for mammalian dihydrofolate reductase than methotrexate is substantially less
Interaction
Folinates given in large amounts may counteract the antiepileptic effect of phenobarbitone, phenytoin and primidone and increase the frequency of seizures in susceptible patients
Contraindications
It is contraindicated to patients with known hypersensitivity to calcium folinate or any other components of this product
Side Effects
The most common side effects are mucositis, stomatitis, leukopenia and/or diarrhea, which may be dose-limiting
Pregnancy & Lactation
There are no adequate and well-controlled clinical studies conducted in pregnant women
Precautions & Warnings
- Calcium folinate should only be used with methotrexate or 5-FU under the direct supervision of a clinician experienced in the use of cancer chemotherapeutic agents
- In general, calcium folinate should not be given simultaneously with folic acid antagonists, e.g. methotrexate, to abort clinical toxicity
Overdose Effects
Excessive amounts of calcium folinate may nullify the chemotherapeutic effect of folic acid antagonists