Sacutril 24 mg+26 mg (Tablet)
Unit Price: ৳ 40.00 (2 x 10: ৳ 800.00)
Strip Price: ৳ 400.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Sacubitril valsartan |
| Company | Synovia pharma plc |
| Also available as |
Indications
- Reduces risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class ll-IV) and reduced ejection fraction
- Treats symptomatic heart failure with systemic left ventricular systolic dysfunction in pediatric patients aged one year and older
- Administered in conjunction with other heart failure therapies
- Administered in place of an angiotensin-converting enzyme inhibitor (ACEi) or other ARB
Pharmacology
- Contains neprilysin inhibitor, sacubitril, and an angiotensin receptor blocker, valsartan
- Inhibits neprilysin (neutral endopeptidase; NEP) via LBQ657, the active metabolite of the prodrug sacubitril
- Blocks the angiotensin II type-1 (AT1) receptor via valsartan
Dosage & Administration
- Recommended starting dose for adults: 49/51 mg orally twice daily
- Recommended maintenance dose for adults: 97/103 mg twice daily
- Recommended dose for pediatric patients aged one year and older
Interaction
- Should not be used with an ACEi, aliskiren in patients with diabetes, and use with an ARB should be avoided
- Potassium-sparing Diuretics may increase serum potassium level
- NSAIDs may increase risk of renal impairment
- Lithium may increase risk of lithium toxicity
Contraindications
- Hypersensitivity to any component
- History of angioedema related to previous ACE inhibitor or ARB therapy
- Concomitant use of ACE inhibitors
- Concomitant use of aliskiren in patients with diabetes
Side Effects
- Angioedema
- Hypotension
- Impaired Renal Function
- Hyperkalemia
- Cough
- Dizziness
Pregnancy & Lactation
- Safety and effectiveness in pediatric patients less than 1 year of age not established
- No relevant pharmacokinetic differences in elderly patients observed
- No dose adjustment required in patients with mild hepatic impairment
Precautions & Warnings
- May cause angioedema
- May lower blood pressure and cause symptomatic hypotension
- Monitor serum creatinine in patients with decreased renal function
- Monitor serum potassium periodically
Use in Special Populations
- Safety and effectiveness in pediatric patients not established
- No relevant pharmacokinetic differences in elderly or very elderly patients observed
- Starting dose adjustment for patients with severe renal impairment and moderate hepatic impairment
Overdose Effects
- Limited data available
- Hypotension is the most likely result of overdosage
- Symptomatic treatment recommended
- Unlikely to be removed by hemodialysis
Storage Conditions
- Store below 30°C
- Protect from moisture
- Keep out of the reach of children