Sacutril 49 mg+51 mg (Tablet)
Unit Price: ৳ 75.00 (2 x 10: ৳ 1,500.00)
Strip Price: ৳ 750.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Sacubitril valsartan |
| Company | Synovia pharma plc |
| Also available as |
Indications
- Reduces risk of cardiovascular death
- Reduces hospitalization for heart failure
- Symptomatic heart failure treatment
- Administered with other heart failure therapies
Pharmacology
- Neprilysin inhibitor
- Sacubitril
- Angiotensin receptor blocker
- Valsartan
- Inhibition of neprilysin
- Inhibition of angiotensin II
- Increased levels of peptides
- Inhibition of aldosterone release
Dosage & Administration
- Recommended starting dose for adult heart failure
- Recommended starting dose for pediatric heart failure
- Recommended dose titration for pediatric patients based on weight
- Dose adjustment for patients with renal impairment
- Dose adjustment for patients with hepatic impairment
Interaction
- Dual blockade of the Renin-Angiotensin-Aldosterone System
- Potassium-sparing Diuretics
- NSAIDs
- Lithium
Contraindications
- Hypersensitivity to any component
- History of angioedema related to previous ACE inhibitor or ARB therapy
- Concomitant use of ACE inhibitors
- Concomitant use of aliskiren in patients with diabetes
Side Effects
- Angioedema
- Hypotension
- Impaired Renal Function
- Hyperkalemia
- Cough
- Dizziness
Pregnancy & Lactation
- Safety and effectiveness in pediatric patients
- No relevant pharmacokinetic differences in elderly patients
- Dose adjustment for hepatic impairment
- Dose adjustment for renal impairment
Precautions & Warnings
- Risk of angioedema
- Potential for symptomatic hypotension
- Monitoring of serum creatinine
- Monitoring of serum potassium
Use in Special Populations
- Safety and effectiveness in pediatric patients
- No relevant pharmacokinetic differences in elderly patients
- Dosage adjustment for renal impairment
- Dosage adjustment for hepatic impairment
Overdose Effects
- Hypotension as likely result
- Symptomatic treatment
- Unlikely to be removed by hemodialysis
Storage Conditions
- Store below 30°C
- Protect from moisture
- Keep out of the reach of children