Xelmet XR 1000 mg (Tablet (Extended Release))

Unit Price: ৳ 10.00 (4 x 7: ৳ 280.00)
Strip Price: ৳ 70.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Beacon pharmaceuticals plc
Also available as
Xelmet 850 mg tablet Xelmet 500 mg tablet Xelmet xr 500 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus
  • Monotherapy in adults
  • Combination therapy in adults
  • Combination therapy in children and adolescents
  • Reduction of diabetic complications
  • First-line therapy after diet failure

Pharmacology

  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Mechanism different from sulfonylureas
  • Does not produce hypoglycemia
  • Decreases hepatic glucose production
  • Decreases intestinal absorption of glucose
  • Improves insulin sensitivity

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerance
  • Maximum recommended daily doses
  • Different dosages for adults and children
  • Immediate release tablet dosing
  • Extended release tablet dosing
  • Instructions for swallowing extended release tablet

Interaction

  • No interaction information with Furosemide
  • Enhancement of absorption by Nifedipine
  • Competition with cationic drugs for renal tubular transport systems
  • No effect on Cimetidine pharmacokinetics
  • Drugs leading to hyperglycemia and loss of glycemic control

Contraindications

  • Hypersensitivity to active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure
  • Conditions altering renal function
  • Conditions causing tissue hypoxia
  • Severe infections or trauma

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decrease in vitamin B12 absorption
  • Peripheral neuropathy in vitamin B12 deficient patients
  • Taste disturbance
  • Encephalopathy
  • Gastrointestinal disorders
  • Liver function test abnormalities
  • Skin reactions

Pregnancy & Lactation

  • Increased risk of congenital abnormalities and perinatal mortality
  • Recommendation to use insulin during pregnancy
  • Excretion of metformin into human breast milk
  • Limited data on breastfeeding
  • Consideration of benefits and potential risks

Precautions & Warnings

  • Excretion by the kidney
  • Risk of Xelmet XR accumulation and lactic acidosis
  • Lowering of vitamin B12 level
  • Increased risk of hypoglycemia in combination therapy
  • Stopping therapy before surgery and clinical investigations
  • Monitoring of renal function
  • Caution in elderly subjects and children

Use in Special Populations

  • Adjustment of metformin dosage in elderly subjects
  • No effect on growth and puberty detected
  • Caution in prepubescent children
  • Regular assessment of renal function
  • Regular estimation of Vitamin B-12 levels
  • Evaluation of renal function before and during treatment

Overdose Effects

  • No hypoglycemia seen with Xelmet XR doses up to 85 gm
  • Occurrence of lactic acidosis
  • Treatment with hemodialysis

Therapeutic Class

  • Biguanides

Storage Conditions

  • Temperature below 30°C
  • Protected from light & moisture
  • Keep out of reach of children

Related Brands