Gentin 80 mg/2 ml (IM/IV Injection)

2 ml ampoule: ৳ 13.99 (5 x 5: ৳ 349.77)

Medicine Details

Category	Details
Generic	Gentamicin sulfate injection
Company	Opsonin pharma ltd
Also available as	Gentin 20 mg injection

Indications

Treatment of serious infections caused by susceptible microorganisms
Septicaemia
Meningitis
Respiratory tract infections
Infected wounds
Skin and skin structure infection
Bone and soft tissue infections
Urinary tract infections

Pharmacology

Bactericidal antibiotic
Active against a broad spectrum of Gram-negative pathogens
Active against some Gram-positive organisms
Interferes with bacterial protein synthesis
Binds to the 30S sub-units of bacterial ribosomes
Cell death results

Dosage & Administration

Administered intramuscularly
Can be administered intravenously if required
Usual adult dose: 3-5 mg/kg/day in three divided doses
Usual pediatric dose: varies by age
Intravenous administration instructions

Interaction

Avoid concurrent use with potentially nephrotoxic or ototoxic drugs
Potent diuretics may potentiate ototoxic effects
Inactivated by solutions containing beta-lactam antibiotics

Side Effects

Vestibular damage
Reversible nephrotoxicity
Auditory ototoxicity
Symptoms include dizziness, vertigo, tinnitus, and hearing loss
May cause adverse renal effects

Pregnancy & Lactation

Safety in pregnancy and lactation not established
Crosses the placenta
Risk of ototoxicity in the fetus
Recommended to discontinue breastfeeding during therapy

Therapeutic Class

Aminoglycosides

Storage Conditions

Store in cool and dry place

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