Gentin 80 mg/2 ml (IM/IV Injection)

Indications

• Treatment of serious infections caused by susceptible microorganisms
• Septicaemia
• Meningitis
• Respiratory tract infections
• Infected wounds
• Skin and skin structure infection
• Bone and soft tissue infections
• Urinary tract infections

Pharmacology

• Bactericidal antibiotic
• Active against a broad spectrum of Gram-negative pathogens
• Active against some Gram-positive organisms
• Interferes with bacterial protein synthesis
• Binds to the 30S sub-units of bacterial ribosomes
• Cell death results

Dosage & Administration

• Administered intramuscularly
• Can be administered intravenously if required
• Usual adult dose: 3-5 mg/kg/day in three divided doses
• Usual pediatric dose: varies by age
• Intravenous administration instructions

Interaction

• Avoid concurrent use with potentially nephrotoxic or ototoxic drugs
• Potent diuretics may potentiate ototoxic effects
• Inactivated by solutions containing beta-lactam antibiotics

Side Effects

• Vestibular damage
• Reversible nephrotoxicity
• Auditory ototoxicity
• Symptoms include dizziness, vertigo, tinnitus, and hearing loss
• May cause adverse renal effects

Pregnancy & Lactation

• Safety in pregnancy and lactation not established
• Crosses the placenta
• Risk of ototoxicity in the fetus
• Recommended to discontinue breastfeeding during therapy

Therapeutic Class

• Aminoglycosides

Storage Conditions

• Store in cool and dry place

Related Brands

• Gentin 20 mg/2 ml (IM/IV Injection) - opsonin-pharma-ltd