Calcigro D Plus (Tablet)

Indications

• Prevention and treatment of osteoporosis
• Maintaining strong bone growth
• Proper functioning of heart, muscle and nerves
• Nutritional supplement
• Bone development and regeneration of bone
• Pregnancy & lactation
• Deficiency state of Calcium, Vitamin D3, Magnesium, Zinc, Copper, Manganese & Boron

Composition

• 600 mg elemental Calcium per film-coated tablet
• 200 IU Vitamin D3 per film-coated tablet
• 40 mg Magnesium per film-coated tablet
• 1.8 mg Manganese per film-coated tablet
• 1 mg Copper per film-coated tablet
• 250 mcg Boron per film-coated tablet
• 7.5 mg Zinc per film-coated tablet
• 600 mg elemental Calcium per effervescent tablet
• 400 IU Vitamin D3 per effervescent tablet
• 40 mg Magnesium per effervescent tablet
• 1.8 mg Manganese per effervescent tablet
• 1 mg Copper per effervescent tablet
• 250 mcg Boron per effervescent tablet
• 7.5 mg Zinc per effervescent tablet

Pharmacology

• Calcium, Magnesium & Vitamin D3 are macronutrients for bone health
• Vitamin D3 crucial for Calcium absorption
• Magnesium increases bone strength
• Micronutrients like Copper, Manganese, Zinc & Boron important for bone health
• Deficiency of micronutrients noticed in patients with osteoporosis

Dosage & Administration

• Adult: 1 film-coated tablet twice daily with water and meals
• Children 3-7 years: 1 effervescent tablet daily
• Children 7 years and older: 1-2 effervescent tablets daily

Interaction

• Risk of hypercalcemia with thiazide diuretics
• Hypocalcemia risk in digitalized patients
• Certain foods reduce calcium absorption
• Concomitant use of phenytoin or barbiturates can decrease Vitamin D3 effect
• Concomitant use of glucocorticoids decreases Vitamin D3 effect
• Calcium salts may reduce absorption of certain medications

Contraindications

• Absolute contraindications for hypercalcemia, primary hyperparathyroidism, Vitamin D3 overdose, severe renal failure
• Relative contraindications for osteoporosis due to prolonged immobilization, renal stones, severe hypercalciuria

Side Effects

• Mild gastro-intestinal disturbances
• Constipation, flatulence, nausea, gastric pain, diarrhea with calcium supplements
• Occasional skin rash with vitamin D3 supplements
• Hypercalciuria and rare cases of hypercalcemia with long term high dose treatment

Pregnancy & Lactation

• Supplementation should be under physician's direction
• Increased calcium and Vitamin D3 requirements during pregnancy and lactation
• Overdose of Vitamin D3 has teratogenic effects in pregnant animals
• Vitamin D3 and metabolites pass into breast milk

Precautions & Warnings

• Careful supervision for mild to moderate renal failure or hypercalciuria
• Periodic checks of plasma calcium levels and urinary calcium excretion needed
• Monitoring of serum and urinary calcium levels and kidney function recommended with long term treatment

Overdose Effects

• Symptoms may include nausea, vomiting, drowsiness, dry mouth, loss of appetite, metallic taste, stomach cramps, diarrhea, headache, constipation

Therapeutic Class

• Specific mineral & vitamin combined preparations

Storage Conditions

• Keep in a dry place away from light and heat
• Keep out of the reach of children

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