E-Max MUPS 20 mg (MUPS Tablet)
Unit Price: ৳ 10.00 (6 x 10: ৳ 600.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Esomeprazole mups preparation |
| Company | Biogen pharmaceuticals ltd |
Title and Categories
- E-Max MUPS 20 mg Tablet
Indications
- Gastro-esophageal Reflux Disease (GERD)
- Risk reduction in NSAID associated gastric ulcer
- H. pylori eradication (Triple therapy)
- Zollinger-Ellison syndrome and idiopathic hypersecretion
Composition
- 133.333 mg (15%w/w) of Esomeprazole enteric coated pellets equivalent to 20 mg Esomeprazole
- 266.67 mg (15% w/w) of Esomeprazole enteric coated pellets equivalent to 40 mg Esomeprazole
Description
- MUPS is abbreviation for Multiple-Unit Pellet System
- Ensures greater bioavailability
- Ensures uniform emptying of micro pellets from stomach into small intestine facilitates rapid dissolution of enteric coating and drug release resulting in early Tmax and Cmax
- Is a combination of fast acting and sustained action
- Once daily dosing
- Ensures lesser chance of localized irritation
- Is better than capsules in reducing the esophageal residence time
- Minimizes fluctuation in plasma concentration of drug
- Ensure rapid and uniform gastric emptying and subsequently uniform drug dissolution of pellets in the gastrointestinal tract due to their small size and larger surface
Pharmacology
- Inhibits gastric acid by blocking the hydrogen-potassium adenosine triphosphatase enzyme system
- Effective for short-term treatment of gastric and duodenal ulcers
Dosage
- 40 mg once daily for 4 weeks (Adult)
- 40 mg once daily for 4 weeks (Children & adolescents)
- 20 mg once daily (Adult)
- 20 mg once daily (Children & adolescents)
- 20 mg once daily for 4-8 weeks (Adult)
- 20 mg twice daily for 7 days (Adult)
- 20 mg twice daily for 7 days (Children & adolescents)
- 40-80 mg twice daily (Adult)
- 10 mg once daily for 8 weeks (Children 1-11 years)
Administration
- Tablets should be swallowed whole with liquid
- Can be dispersed in half a glass of non-carbonated water
- Pellets must not be chewed or crushed
Interaction
- Extensively metabolized in the liver by CYP2C19 and CYP3A4
- Not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1 and 3A4
- Potentially interferes with CYP2C19
- Does not have any clinically significant interactions with specific drugs
- May interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability
- Co-administration with clarithromycin has resulted in increases in the plasma levels
Contraindications
- Known hypersensitivity to any of the formulation
Side Effects
- Headache
- Diarrhea
- Nausea
- Flatulence
- Abdominal pain
- Constipation
- Dry mouth
Pregnancy & Lactation
- Manufacturer advises caution
- Not known if Esomeprazole or its metabolites appear in human breast milk
Precautions & Warnings
- Should be used carefully with severe liver dysfunction and severe renal impairment
- May slightly increase the risk of hip, wrist and spine fracture over a period of more than one year
Storage Conditions
- Store in a cool & dry place below 25°C
- Protect from light
- Keep out of reach of children
Chemical Structure
- Molecular Formula: C17H19N3O3S
- Chemical Structure Image: [Link to chemical structure image]
Common Questions
- What is E-Max MUPS 20 mg MUPS Tablet
- What is MUPS Tablet
- What is E-Max MUPS 20 mg MUPS Tablet used for
- What are the side effects of E-Max MUPS 20 mg MUPS Tablet
- Can I take E-Max MUPS 20 mg MUPS Tablet if I am pregnant or breastfeeding
- How long does it take for E-Max MUPS 20 mg MUPS Tablet to work