Esmogel 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Esomeprazole
Company Biogen pharmaceuticals ltd
Also available as
Esmogel 20 mg capsule

Indications

  • Relieves chronic heartburn symptoms
  • Heals erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Treatment of Zollinger-Ellison Syndrome
  • Relief from acid-related Dyspepsia
  • Treatment of duodenal and gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppresses gastric acid secretion
  • Specific inhibition of the H+/K+-ATPase
  • Enteric-coated pellet formulation
  • Peak plasma levels at approximately 1.5 hours
  • Metabolized in the liver by CYP enzymes
  • Low urinary excretion

Dosage

  • Oral dosage form for healing and maintenance of erosive esophagitis, symptomatic GERD, Helicobacter pylori eradication, Zollinger-Ellison Syndrome, acid-related Dyspepsia, duodenal and gastric ulcer
  • IV injection or infusion for GERD with erosive esophagitis and risk reduction of rebleeding of gastric or duodenal ulcers

Administration

  • Tablet or capsule should be swallowed whole one hour before a meal
  • Oral suspension should be taken with water
  • IV injection solution must be administered intravenously over at least 3 minutes

Interactions

  • Extensively metabolized by CYP2C19 and CYP3A4
  • No inhibition of CYPs 1A2, 2A6, 2C9, 2D6, 2E1, and 3A4
  • No clinically relevant interactions with specific drugs
  • Potential interference with drugs affected by gastric pH
  • Increased plasma levels when combined with certain drugs

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • No teratogenic effects in animal studies
  • Excretion in milk not studied
  • Breastfeeding discontinuation if essential

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Advice for patients on capsule administration and use of antacids

Use in Special Populations

  • Safety and effectiveness not established in pediatric patients
  • No overall differences in safety and efficacy in the elderly
  • No dosage adjustment required for mild to moderate hepatic insufficiency
  • No alteration in pharmacokinetics in renal impairment

Overdose Effects

  • Lethal in high doses in rat studies
  • Symptomatic and supportive treatment recommended
  • Not expected to be removed by dialysis

Storage Conditions

  • Store at a temperature not exceeding 30°C
  • Dry place, protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure Image URL

Common Questions

  • Description of Esmogel 40 mg Capsule as a proton pump inhibitor
  • Multiple uses of Esmogel 40 mg Capsule
  • Common side effects of Esmogel 40 mg Capsule
  • Recommendation to discuss use during pregnancy or breastfeeding with a doctor
  • Estimated time for Esmogel 40 mg Capsule to start working
  • Quick tips for using Esmogel 40 mg Capsule

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