Nemine 4 mg (Tablet)

Indications

• Urticaria
• Sensitivity reactions
• Angioneurotic edema
• Vasomotor rhinitis
• Cough
• Common cold
• Motion sickness
• Other allergic conditions

Pharmacology

Chlorpheniramine Maleate is an alkylamine antihistamine. It is one of the most potent histamine H1-receptor blocking agents which is used as a potent antihistamine. This generally causes less sedation than promethazine. Chlorpheniramine Maleate exerts its effects by blocking H1-receptor competitively.

Dosage & Administration

• Adult: Usual adult dose is 4 mg every 4-6 hours, maximum 24 mg daily.
• Child:
  • 6-12 years: 2 mg every 4-6 hours, maximum 12 mg daily
  • 2-5 years: 1 mg every 4-6 hours, maximum 6 mg daily
  • 1-2 years: 1 mg twice daily

Interaction

Chlorphenamine maleate has been reported to be incompatible with calcium chloride, kanamycin sulfate, noradrenaline acid tartrate, pentobarbital sodium, and meglumine adipiodone.

Contraindications

Chlorpheniramine is contraindicated in patients hypersensitive to this agent, in newborn or premature infants

Side Effects

Nemine is well-tolerated, but sometimes drowsiness, dizziness, muscular weakness, and gastrointestinal upset may occur

Pregnancy & Lactation

This drug should not be used in lactating mother and in pregnancy especially during the first trimester of pregnancy

Precautions & Warnings

Nemine should be used with caution in patients with glaucoma and prostatic hypertrophy. During therapy with chlorpheniramine, caution should be taken in driving vehicles and operating machinery

Overdose Effects

CNS depression (including sedation, apnea, CV collapse), CNS stimulation (including insomnia, hallucination, tremors, convulsions), tinnitus, blurred vision, dizziness, ataxia, hypotension. Stimulation and atropine-like signs and symptoms (including dry mouth, fixed dilated pupils, flushing, hyperthermia, Gl symptoms) are more likely in children

Therapeutic Class

Sedating Anti-histamine

Storage Conditions

Store in a cool (Below 25°C temperature) and dry place protected from light. Keep out of the reach of children

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