Rabetol 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 6.00 (5 x 14: ৳ 420.00)
Strip Price: ৳ 84.00

Medicine Details

Category Details
Generic Rabeprazole sodium
Company Biogen pharmaceuticals ltd

Indications

  • Active duodenal ulcer
  • Active benign gastric ulcer
  • Symptomatic erosive or ulcerative gastro-esophageal reflux disease (GERD)
  • Gastro-esophageal Reflux Disease Long-term Management (GERD Maintenance)
  • Symptomatic treatment of moderate to very severe gastro-esophageal reflux disease (symptomatic GERD)
  • Zollinger-Ellison Syndrome
  • In combination with appropriate antibacterial therapeutic regimens for the eradication of Helicobacter pylori in patients with peptic ulcer disease

Pharmacology

  • Suppression of gastric acid secretion
  • Inhibition of the gastric H+/K+-ATPase enzyme
  • Characterized as a gastric proton-pump inhibitor

Dosage

  • Recommended oral doses for active duodenal ulcer and active benign gastric ulcer
  • Recommended oral dose for erosive or ulcerative gastro-esophageal reflux disease (GERD)
  • Recommended oral dose for long-term management of GERD
  • Symptomatic treatment of moderate to very severe gastro-esophageal reflux disease (symptomatic GERD)
  • Treatment of GERD in pediatric patients 1 to 11 years of age
  • Recommended adult starting dose for Zollinger-Ellison Syndrome
  • Recommended eradication therapy for H. pylori infection

Administration

  • Tablets to be taken in the morning
  • Tablets should not be chewed or crushed, but swallowed whole

Interaction

  • Potential interaction with compounds whose absorption is pH dependent
  • Possible decrease in antifungal plasma levels when co-administered with ketoconazole or itraconazole
  • No observed interaction with liquid antacids
  • Absorption of atazanavir is pH-dependent, hence caution advised for concurrent use

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Contra-indicated in pregnancy and during breastfeeding

Side Effects

  • Well-tolerated in both short-term and long-term studies
  • Possible side effects: headache, diarrhea, abdominal pain, vomiting, constipation, dry mouth, changes in appetite, muscle pain, drowsiness, dizziness

Pregnancy & Lactation

  • US FDA pregnancy category 'C'
  • No adequate and well-controlled studies in pregnant women
  • Possible excretion in human milk, necessitating decision on continuation based on risk-benefit assessment

Precautions & Warnings

  • Symptomatic response does not exclude possibility of malignancy
  • Regular surveillance for long-term treatment patients
  • Potential increase in risk of hip, wrist, and spine fractures, especially in the elderly or with other risk factors
  • Possible cross-hypersensitivity reactions with other proton pump inhibitors or substituted benzimidazoles
  • Caution for patients with hepatic impairment

Use in Special Populations

  • No dosage adjustment for patients with renal or hepatic impairment
  • Not recommended for use in children due to lack of data on safety and efficacy

Overdose Effects

  • Maximum established exposure
  • Effects generally minimal, reversible without further medical intervention
  • No specific antidote
  • Not dialysable due to extensive protein binding

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep below 30°C temperature
  • Away from light and moisture
  • Keep out of the reach of children

Chemical Structure

  • Molecular Formula: C18H21N3O3S

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