Tolfamax 200 mg (Tablet)

Title

• Tolfamax 200 mg Tablet

Categories

• Pain Relief
• Anti-inflammatory
• Migraine Relief
• Analgesic
• NSAID

Dosage and administration

• Recommended dosage for acute migraine attacks: 200 mg when symptoms appear
• Dosage for mild to moderate pain: 100-200 mg tid
• Dose adjustments needed for renal impairment
• Avoid in case of severe renal impairment
• Pediatric dosage regimen not established
• Should be taken with food

Pharmacology

• Potent inhibitor of cyclooxygenase enzyme
• Inhibits synthesis of inflammatory mediators like thromboxane and prostaglandin
• Has direct antagonistic action on prostaglandin receptors
• Reaches peak plasma concentration in 60-90 min
• Has a bioavailability of 85%
• Undergoes enterohepatic circulation
• Metabolized in the liver
• Excreted in urine and feces

Interactions

• Rate of absorption affected by Metoclopramide and Magnesium hydroxide
• Decreases with Aluminium hydroxide
• Increases risk of bleeding with anticoagulants and other NSAIDs
• Decreases antihypertensive response to loop diuretics, B-blockers and ACE Inhibitors
• Increases plasma concentration of Lithium, Methotrexate, and cardiac glycosides
• Increases risk of nephrotoxicity with ACE inhibitors, Ciclosporin, Tacrolimus, or diuretics

Contraindications

• Active gastrointestinal bleeding
• Active gastrointestinal ulceration
• History of gastrointestinal bleeding related to previous NSAID therapy
• History of gastrointestinal haemorrhage
• History of gastrointestinal perforation related to previous NSAID therapy
• History of recurrent gastrointestinal ulceration
• Severe heart failure

Indications

• Relieving the pain of migraine headache
• Analgesic in post-operative pain and fever

Side effects

• Rare side effects include alveolitis, hepatic damage, pancreatitis
• Common side effects: depression, diarrhea, dizziness, drowsiness, dysuria, euphoria, gastrointestinal bleeding, discomfort, hallucination, insomnia, malaise, nausea
• Other side effects: hearing disturbances, rash, visual disturbances, vertigo, raised blood pressure
• Symptoms of overdose include headache, vomiting, gastrointestinal bleeding, convulsion, acute renal failure, liver damage

Precautions and warnings

• Precaution needed for patients with asthma, bleeding disorders, cardiovascular diseases, peptic ulceration, hypertension, liver or renal function impairment, and elderly
• Increase water intake or dose reduction to reduce dysuria

Pregnancy and lactation

• Not recommended during pregnancy unless considered essential by a doctor
• Avoid during the third trimester of pregnancy
• NSAIDs can appear in breast milk in very low concentrations

Drug therapeutic class

• Rheumatoid Arthritis drugs
• Non-steroidal Anti-inflammatory Drugs (NSAIDs)
• Migraine drugs

Storage conditions

• Store in a cool, dry place away from light
• Keep out of the reach of children

Chemical structure

• Molecular Formula: C14H12ClNO2

Common questions

• What is Tolfamax 200 mg Tablet used for?
• What are the uses of Tolfamax 200 mg Tablet?
• Quick tips for taking Tolfamax 200 mg Tablet

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• Niltuf 200 mg (Tablet) - veritas-pharmaceuticals-ltd