Paclitaxel 6 mg/ml (IV Infusion)
30 mg vial: ৳ 2,100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Paclitaxel |
| Company | Seacross pharmaceuticals ltd |
Indications
- Treatment of advanced carcinoma of the ovary
- Adjuvant treatment of node-positive breast cancer
- First-line therapy of advanced or metastatic breast cancer
- First-line treatment of non-small cell lung cancer
- Second line treatment of AIDS-related Kaposi's Sarcoma
Pharmacology
- Promotes microtubule assembly
- Stabilizes microtubules
- Induces abnormal arrays of microtubules
- Inhibits dynamic reorganization of microtubule network
Dosage & Administration
- Premedication required before administration
- Recommended dosages for ovarian cancer, breast carcinoma, non-small cell lung cancer, Kaposi's Sarcoma
- Dose adjustment based on individual patient tolerance
Interaction
- Cisplatin interaction
- Doxorubicin interaction
- Metabolism by CYP2C8 and CYP3A4 enzymes
- Inhibition and induction of CYP2C8 and CYP3A4 enzymes
Contraindications
- Severe hypersensitivity reactions
- Contraindicated during lactation
- Baseline neutrophil and platelet count contraindications
- Severe hepatic impairment contraindication
Side Effects
- Low blood counts
- Hair loss
- Neuropathy
- Nausea and vomiting
- Hypersensitivity reactions
- Liver problems
- Edema
- Low blood pressure
- Darkening of the skin
Pregnancy & Lactation
- Pregnancy Category D
- Contraindicated during lactation
Precautions & Warnings
- Administered under supervision of experienced physician
- Supportive equipment for hypersensitivity reactions
- Monitoring for extravasation during drug administration
- Bone marrow suppression
- Severe cardiac conduction abnormalities
Use in Special Populations
- Dose reduction for severe neutropenia or neuropathy
- Hepatic impairment precautions
- Not recommended for pediatric use
Overdose Effects
- No known antidote
- Monitor closely for bone marrow suppression, neurotoxicity, and mucositis
Reconstitution
- Must be diluted prior to infusion
- Options for dilution
- Stability of solutions
- Visual inspection prior to administration
Storage Conditions
- Store below 30°C
- Protection from light
- Freshly prepared solution required