GBpoietin 4000 IU (IV/SC Injection)

4000 IU pre-filled syringe: ৳ 2,650.12

Medicine Details

Category Details
Generic Erythropoietin alfa
Company Globe biotech limited
Also available as
Gbpoietin 2000 iu injection Gbpoietin 5000 iu injection Gbpoietin 10000 iu injection

Therapeutic Class

  • Drugs for Haemolytic Hypoplastic & Renal Anemia

Indications

  • Treatment of anemia in Chronic Kidney Disease (CKD) patients on dialysis and not on dialysis
  • Treatment of anemia in Zidovudine-treated HIV-infected patients
  • Treatment of anemia in patients undergoing myelosuppressive chemotherapy
  • Reduction of allogeneic RBC transfusions in patients undergoing elective, noncardiac, nonvascular surgery
  • Prevention of anemia of prematurity in infants with a birth weight of 750 to 1500 gm and gestational age of less than 34 weeks

Description

  • Recombinant human erythropoietin (EPO)
  • Expressed in Chinese hamster ovary cells
  • 165 amino acid sequence identical to human urinary EPO
  • Apparent molecular weight of erythropoietin is about 30,400 daltons

Dosage

  • Regular monitoring of hemoglobin levels
  • Evaluation of iron stores and nutritional factors before and during treatment
  • Adjustment of therapy based on hemoglobin rate of rise, rate of decline, ESA responsiveness, and hemoglobin variability
  • Different dosing guidelines for CKD patients on dialysis and not on dialysis, Zidovudine-treated HIV-infected patients, and cancer chemotherapy patients

Administration

  • Preparation and administration precautions
  • Do not shake the product
  • Protect syringe from light
  • Visual inspection for particulate matter and discoloration prior to administration
  • Discard unused portions of Erythropoietin alfa

Interaction

  • Potentiation by simultaneous therapeutic administration of a haematinic agent like ferrous sulphate

Contraindications

  • Uncontrolled hypertension
  • Serious allergic reactions to Erythropoietin alfa
  • History of Pure Red Cell Aplasia (PRCA) following treatment with any erythropoietin

Side Effects

  • Adverse reactions reported in patients with CKD, Zidovudine-treated HIV-infected Patients, cancer patients on chemotherapy, surgery patients, and premature infants

Pregnancy & Lactation

  • Limited data in pregnant women
  • Reproduction toxicology observed in animals
  • Use in pregnancy only if potential benefit outweighs potential risk to the fetus
  • Caution advised in nursing women

Overdose Effects

  • Wide therapeutic margin
  • Can cause hemoglobin levels above the desired range
  • Management with discontinuation or reduction of dosage and/or phlebotomy
  • Severe hypertension observed in cases of overdose

Storage Conditions

  • Store at 2°C to 8°C
  • Do not freeze or shake
  • Maintain temperature range until administration
  • Store in original package to protect from light

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