Xaparin 6000 Anti-Xa IU/0.6 ml (SC Injection)

Indications

• Treatment of deep vein thrombosis
• Treatment of unstable angina and non-Q-wave myocardial infarction
• Prevention of thrombus formation in the extra-corporeal circulation during haemodialysis
• Prophylaxis of venous thromboembolic disease in surgical and medical patients

Composition

• 0.2 ml pre-filled syringe contains Enoxaparin Sodium BP 20 mg
• 0.4 ml pre-filled syringe contains Enoxaparin Sodium BP 40 mg
• 0.6 ml pre-filled syringe contains Enoxaparin Sodium BP 60 mg
• 0.8 ml pre-filled syringe contains Enoxaparin Sodium BP 80 mg

Pharmacology

• Low molecular weight heparin with high anti-Xa activity
• No notable modification of activated Partial Thromboplastin Time (aPTT)
• Primarily metabolised in the liver

Dosage

• Different doses for different indications and patient types
• Subcutaneous administration
• Oral anticoagulant therapy initiation
• Dosage adjustments for hemodialysis patients
• Specific doses for surgical and medical patients

Administration

• Injection site preparation and selection
• Dose preparation and adjustment
• Injection technique and disposal
• Instructions for self-injection

Interaction

• Recommendations for discontinuing agents affecting hemostasis before therapy

Contraindications

• Known hypersensitivity to Enoxaparin Sodium
• Active major bleeding
• High risk of uncontrolled hemorrhage

Side Effects

• Haemorrhage (bleeding)
• Thrombocytopenia
• Elevations of serum aminotransferase
• Pain, bluish marks, skin rash at injection sites
• Neuraxial hematomas with concurrent use of Xaparin and spinal/epidural anesthesia or spinal puncture

Pregnancy & Lactation

• Pregnancy category B
• Unknown excretion in human milk
• Special consideration for pregnant women with mechanical prosthetic heart valves

Precautions & Warnings

• Deep subcutaneous route for administration
• Caution in conditions with increased potential for bleeding
• Platelet count monitoring
• No intramuscular administration

Use in Special Populations

• Special considerations in elderly patients, renal impairment, and hepatic impairment

Overdose Effects

• Accidental overdosage may lead to hemorrhagic complications
• Neutralization using protamine sulfate

Therapeutic Class

• Parenteral anti-coagulants

Storage Conditions

• Store in a cool and dry place
• Protect from light and moisture
• Do not refrigerate or freeze

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