Zodef 18 mg (Tablet)
Unit Price: ৳ 20.00 (2 x 10: ৳ 400.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Deflazacort |
| Company | Renata limited |
| Also available as |
Indications
- Anaphylaxis
- Asthma
- Severe hypersensitivity reactions
- Rheumatoid arthritis
- Juvenile chronic arthritis
- Polymyalgia rheumatica
- Systemic lupus erythematosus
- Dermatomyositis
- Mixed connective tissue disease
- Polyartritis nodosa
- Sarcoidosis
- Pemphigus
- Bullous pemphigoid
- Pyoderma gangrenosum
- Minimal change nephrotic syndrome
- Acute interstitial nephritis
- Rheumatic carditis
- Ulcerative colitis
- Crohn's disease
- Uveitis
- Optic neuritis
- Autoimmune haemolytic anaemia
- Idiopathic thrombocytopenic purpura
- Acute and lymphatic leukaemia
- Malignant lymphoma
- Multiple myeloma
- Immune suppression in transplantation
Pharmacology
- Anti-inflammatory action
- Inhibition of Phospholipase A2 enzyme
- Prostaglandin synthesis inhibition
- Immunosuppressive action
- Decreased release of immune system chemicals
Dosage & Administration
- Maximum adult dose up to 120 mg/day for acute disorders
- Maintenance adult doses within the range of 3-18 mg/day
- Range of maintenance doses for various conditions
- Limited exposure of children to Deflazacort in clinical trials
- Usual maintenance dose for juvenile chronic arthritis
- Initial dose for nephrotic syndrome
- Deflazacort withdrawal guidance
Interaction
- Metabolized in the liver
- Recommendation for adjusting maintenance dose with liver enzyme inducers
- Possibility to reduce maintenance dose with liver enzyme inhibitors
Contraindications
- Hypersensitivity to ingredients
- Patients receiving live virus immunization
Side Effects
- GI disturbances
- Musculoskeletal effects
- Endocrine effects
- Neuropsychiatric effects
- Ophthalmic effects
- Fluid and electrolyte disturbances
- Increased susceptibility to infection
- Impaired healing
- Hypersensitivity reactions
- Skin atrophy
- Striae
- Telangiectasia
- Acne
- Myocardial rupture risk following recent myocardial infarction
- Thromboembolism risk
Pregnancy & Lactation
- Crosses the placenta
- Potential to increase risk of intrauterine growth retardation
- Prescription considerations in pregnancy
- Excretion in breast milk
- Unlikely systemic effects in infant with doses up to 50 mg daily
- Potential for adrenal suppression in infants with higher maternal doses
Precautions & Warnings
- Special caution for various clinical conditions
- Requirement for frequent patient monitoring
- Specific precautions for cardiac disease, hypertension, thromboembolic disorders
- Special caution for gastrointestinal and intestinal conditions
- Precautions for diabetes mellitus, osteoporosis, myasthenia gravis, renal insufficiency
- Emotional instability and psychotic tendency precautions
- Precautions for liver failure, hypothyroidism, cirrhosis, ocular herpes simplex
Use in Special Populations
- Monitoring and dose adjustments for hepatic impairment
- No special precautions for renally impaired patients
- No special precautions for elderly patients
Therapeutic Class
- Glucocorticoids
Storage Conditions
- Cool and dry place
- Protected from light and moisture
- Keep out of the reach of children