Emistat FT 8 mg (Flash Tablet)

Unit Price: ৳ 11.00 (3 x 10: ৳ 330.00)
Strip Price: ৳ 110.00

Medicine Details

Category Details
Generic Ondansetron
Company Healthcare pharmaceuticals ltd
Also available as
Emistat ft 4 mg flash tablet Emistat 8 mg tablet Emistat 8 mg injection Emistat 4 mg oral solution

Indications

  • Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy
  • Prevention and treatment of post-operative nausea and vomiting
  • Prevention of radiotherapy-induced nausea and vomiting

Description

  • Orally dissolving film
  • Applies on top of the tongue
  • Dissolves within 20 seconds
  • Active ingredient: Emistat FT base
  • Selective blocking agent of serotonin 5-HT3 receptor type
  • Empirical formula: C18H19N3O
  • Molecular weight: 293.3

Pharmacology

  • Potent, highly selective 5HT3 receptor-antagonist
  • Mode of action in control of nausea and vomiting not fully known

Dosage

  • Doses for chemotherapy-induced nausea and vomiting for adults and pediatric patients
  • Doses for radiotherapy-induced nausea and vomiting for adults
  • Doses for postoperative nausea and vomiting for adults and pediatrics
  • Doses for different types of cancer chemotherapy and radiotherapy for various age groups
  • Oral solution and oral soluble film dosages

Administration

  • Application steps for oral soluble film
  • Tear the pouch carefully
  • Place the film on top of the tongue
  • Do not chew or swallow the film whole
  • Swallow after the film dissolves
  • Wash hands after taking the film

Interaction

  • Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes
  • Clearance and half-life may be changed by inducers or inhibitors of these enzymes

Contraindications

  • Hypersensitivity to the drug or any of its components
  • Concomitant use of apomorphine

Side Effects

  • Frequently reported adverse events: headache, constipation, diarrhea
  • Rare cases of anaphylaxis, brochospasm, tachycardia
  • Reports of flushing or warmth, hiccups, liver enzyme abnormalities
  • No evidence of extrapyramidal reactions in PONV

Pregnancy & Lactation

  • No evidence of carcinogenic effects in rat and mice studies
  • Not mutagenic in standard tests for mutagenicity
  • No evidence of impaired fertility or harm to fetus in animal studies
  • Excreted in the breast milk of rats
  • Caution advised during nursing

Precautions & Warnings

  • Hypersensitivity reactions reported in patients sensitive to other 5-HT3 receptor antagonists
  • Not a stimulant of gastric or intestinal peristalsis
  • Should not be used instead of nasogastric suction
  • May mask a progressive ileus and/or gastric distension

Use in Special Populations

  • Dosage adjustment for impaired renal function same as general population
  • Dosage adjustment for severe hepatic impairment
  • Limited information on dosage for pediatric patients 4 years of age or younger
  • No dosage adjustment needed for patients over 65 years old

Therapeutic Class

  • Anti-emetic drugs

Storage Conditions

  • Store at temperature not exceeding 30°C
  • Dry place
  • Protect from light and moisture

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