Renvista 100 mg (Tablet)
Unit Price: ৳ 600.00 (1 x 3: ৳ 1,800.00)
Strip Price: ৳ 1,800.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Roxadustat |
| Company | Aristopharma ltd |
| Also available as |
Indications
- Treatment of symptomatic anemia associated with chronic kidney disease (CKD) in adult patients
Description
- First-in-class orally administered HIF-PH inhibitor
- Promotes erythropoiesis
- Increases endogenous production of erythropoietin
- Improves iron regulation
- Overcomes EPO-suppressive effects of inflammation
- Downregulates hepcidin
Pharmacology
- Orally bioavailable
- Hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI)
- Promotes HIF activity
- Increases endogenous erythropoietin production
- Reduces hepcidin expression
- Improves iron availability
- Boosts hemoglobin (Hb) levels
Dosage & Administration
- Oral administration
- Taken three times per week
- Individualized dose for target Hb levels (10-12 g/dL)
- Dose adjusted based on patient's condition
- Dosage range: 50-400 mg (based on patient weight and previous treatment)
Interaction
- Potential drug-drug interactions with phosphate binders, gemfibrozil, probenecid, and certain statins
- Recommendations for dose adjustments based on Hb monitoring
Side Effects
- Common adverse reactions include hypertension, vascular access thrombosis, diarrhea, peripheral edema, hyperkalemia, and nausea
Pregnancy & Lactation
- Contraindicated during pregnancy and breastfeeding
Precautions & Warnings
- Use with caution in patients with pre-existing risk factors for thrombotic vascular events (TVEs)
- Precautions for patients with history of seizures, signs of infection, and liver disorder
- Not to be initiated in pregnant women
Use in Special Populations
- Not indicated for use in children
- Not recommended for patients with severe hepatic impairment
Overdose Effects
- Symptoms include increased heart rate and excessive hemoglobin concentration
- Treatment involves appropriate dose reduction or interruption
Therapeutic Class
- Drugs for Haemolytic Hypoplastic & Renal Anemia
Storage Conditions
- Store in a cool, dry place below 30°C
- Keep away from light and moisture
- Keep out of the reach of children