Progency 10 mg (Tablet)

Unit Price: ৳ 30.00 (2 x 10: ৳ 600.00)
Strip Price: ৳ 300.00

Medicine Details

Category Details
Generic Dydrogesterone
Company Healthcare pharmaceuticals ltd

Therapeutic Class

  • Female Sex hormones

Indications

  • Treatment of threatened miscarriage
  • Treatment of habitual miscarriage
  • Treatment of dysmenorrhoea
  • Treatment of endometriosis
  • Treatment of secondary amenorrhoea
  • Treatment of irregular cycles
  • Treatment of dysfunctional uterine bleeding
  • Treatment of infertility due to luteal insufficiency
  • Luteal support as part of an Assisted Reproductive Technology (ART)
  • To counteract the effects of unopposed oestrogen on the endometrium in hormone replacement therapy for women with disorders due to natural or surgical induced menopause with an intact uterus

Pharmacology

  • Orally-active progestogen
  • Produces complete secretory endometrium in an oestrogen-primed uterus
  • Protection against increased risk for endometrium hyperplasia and carcinogenesis induced by oestrogens
  • No oestrogenic, androgenic, thermogenic, anabolic, or corticoid activity

Dosage & Administration

  • Take exactly as prescribed by the doctor

Dosage for Progesterone deficiencies

  • Threatened miscarriage: 40 mg (four tablets) at once, then 10 mg (one tablet) every eight hours until symptoms remit
  • Habitual miscarriage: 10 mg (one tablet) twice daily until the twentieth week of pregnancy
  • Dysmenorrhoea: 10 mg (one tablet) twice daily from day 5 to day 25 of the menstrual cycle
  • Endometriosis: 10 mg (one tablet) two or three times daily from day 5 to day 25 of the cycle or continuously
  • Dysfunctional bleeding (to arrest bleeding): 10 mg (one tablet) twice daily for five to seven days
  • Dysfunctional bleeding (to prevent bleeding): 10 mg (one tablet) twice daily from day 11 to day 25 of the cycle
  • Amenorrhoea: An oestrogen once daily from day 1 to day 25 of the cycle, together with 10 mg Presentation twice daily from day 11 to day 25 of the cycle
  • Irregular cycles: 10 mg (one tablet) twice daily from day 11 to day 25 of the cycle
  • Infertility due to luteal insufficiency: 10 mg (one tablet) daily from day 14 to day 25 of the cycle. The treatment should be continued for at least 6 consecutive cycles. It is advisable to continue this treatment during the first month of any pregnancy using the doses stated with respect to habitual miscarriage
  • Luteal support as part of an Assisted Reproductive Technology (ART) treatment: 10 mg three times daily (three tablets daily) starting at the day of oocyte retrieval and continuing for 10 weeks if pregnancy is confirmed

Dosage for Hormone Replacement Therapy

  • In combination with continuous oestrogentherapy, take one tablet daily for 14 consecutive days of a 28 day cycle
  • In combination with cyclical oestrogen therapy take one tablet daily during the last 12 to 14 days of oestrogen therapy
  • If endometrial biopsies or ultrasound reveal inadequate Presentationational response, 20 mg Dydrogesterone should be prescribed

Contraindications

  • Known hypersensitivity to the active substance or to any of the excipients
  • Known or suspected progestogen dependent neoplasms (e.g. meningioma)

Side Effects

  • Migraines/headache
  • Nausea
  • Menstrual disorders
  • Breast pain/tenderness

Pregnancy & Lactation

  • No harmful effect of Dydrogesterone use during pregnancy
  • No data on excretion of Dydrogesterone in mother's milk
  • Progestogens and the metabolites pass to mother's milk in small quantities
  • Dydrogesterone should not be used during the lactation period

Precautions & Warnings

  • Before initiating treatment for abnormal bleeding, clarify the etiology
  • Breakthrough bleeding and spotting may occur during the first months of treatment
  • Investigate the reason for breakthrough bleeding or spotting
  • Monitor for severe headache, migraine, symptoms indicating cerebral ischemia, marked increase in blood pressure, occurrence of venous thromboembolism (VTE)
  • In cases of habitual or threatened abortion, ascertain the viability of the foetus
  • Carefully monitor patients with a history of depression

Overdose Effects

  • Progency was well tolerated after oral dosing (maximum daily dose is 360 mg)
  • No reports of ill effects from overdose
  • If a large overdose is discovered within two or three hours, consider gastric lavage

Storage Conditions

  • Store at below 30°C in a dry place protected from light
  • Keep out of reach of children

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