Folidel 15 mg (Tablet)

Unit Price: ৳ 25.00 (3 x 10: ৳ 750.00)
Strip Price: ৳ 250.00

Medicine Details

Category Details
Generic Folinic acid
Company Delta pharma ltd
Also available as
Folidel 5 mg tablet

Indications

  • Neutralising the immediate toxic effects of folic acid antagonists, e.g. methotrexate
  • Calcium folinate rescue- a treatment technique using calcium folinate in conjunction with folic acid antagonists, e.g. methotrexate, to minimise systemic toxicity
  • The treatment of megaloblastic anaemias due to sprue, nutritional deficiency, pregnancy, infancy, liver disease and malabsorption syndrome

Composition

  • 6.249 mg Calcium Folinate Hydrate BP equivalent to 5 mg Folinic Acid
  • 18.746 mg Calcium Folinate Hydrate BP equivalent to 15 mg Folinic Acid

Pharmacology

  • Calcium Folinate Hydrate is the calcium salt of folinic acid, involved as a cofactor for 1-carbon transfer reactions in the biosynthesis of purine and pyrimidines of nucleic acids
  • Impairment of thymidylate synthesis in patients with folic acid deficiency leads to megaloblast formation and megaloblastic and macrocytic anemias
  • Potent antidote for both hematopoietic and reticuloendothelial toxic effects of folic acid antagonists, e.g. methotrexate
  • Postulated to 'rescue' normal cells from the toxic effects of folic acid antagonists, in preference to tumor cells

Dosage & Administration

  • Calcium folinate rescue treatment dosage
  • Dose of methotrexate that triggers the subsequent Folinic Acid administration
  • Dose regimen for hematologic toxicity from folic acid antagonists with less affinity for mammalian dihydrofolate reductase
  • Dose for neutralising the immediate toxic effects of folic acid antagonists
  • Dose for megaloblastic anemia (folate deficiency)
  • Use in children and adolescents

Interaction

  • Counteraction of antiepileptic effect of phenobarbitone, phenytoin and primidone
  • Increase the frequency of seizures in susceptible patients
  • Caution with concurrent administration of calcium folinate with fluoropyrimidine

Contraindications

  • Known hypersensitivity to calcium folinate or any other components of this product
  • Pernicious anemia or other megaloblastic anemia where vitamin B12 is deficient
  • Rare hereditary problems of galactose intolerance, the lapp lactase deficiency or glucose-galactose malabsorption

Side Effects

  • Mucositis
  • Stomatitis
  • Leukopenia
  • Diarrhea

Pregnancy & Lactation

  • Use in pregnant women if the potential benefit justifies the potential risk to the fetus
  • Excretion in human milk

Precautions & Warnings

  • Use with methotrexate or 5-FU under the direct supervision of a clinician experienced in the use of cancer chemotherapeutic agents
  • Inadvertent overdosage treatment
  • Not to be given simultaneously with folic acid antagonists, e.g. methotrexate, to abort clinical toxicity
  • Measures to ensure the prompt excretion of methotrexate

Overdose Effects

  • No reported sequelae
  • Nullity of the chemotherapeutic effect of folic acid antagonists
  • No specific antidote

Therapeutic Class

  • Supportive Care Therapy

Storage Conditions

  • Do not store above 30°C
  • Keep away from light
  • Keep out of the reach of children

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