Metsa XR 750 mg (Tablet (Extended Release))
Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Synovia pharma plc |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Management of diabetes in overweight patients
- Reduction of diabetic complications in adults
- Use in children from 10 years of age and adolescents
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Maximum recommended daily doses
- Different dosage for immediate release and extended release tablet
Interaction
- Minimal effect on Nifedipine
- Cationic drugs potential interaction
- Effects on Cimetidine pharmacokinetics
- Drugs that tend to produce hyperglycemia
Contraindications
- Hypersensitivity to the active substance
- Conditions causing tissue hypoxia
- Severe renal failure
- Acute metabolic acidosis
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Peripheral neuropathy
- Taste disturbance
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Risk of congenital abnormalities and perinatal mortality
- Excretion into human breast milk
- Limited data on breastfeeding during treatment
Precautions & Warnings
- Excretion by the kidney
- Lowered vitamin B12 level
- Increased risk of hypoglycemia
- Monitoring of renal function
- Annual estimation of Vitamin B-12 levels
- Possible interactions with other drugs
Use in Special Populations
- Elderly dosage adjustment based on renal function
- No effect on growth and puberty in controlled clinical studies
- Precaution when prescribing to children aged between 10 and 12 years
- Regular renal function assessment
Overdose Effects
- No hypoglycemia seen with doses up to 85g
- Lactic acidosis is a medical emergency
- Treatment with hemodialysis
Therapeutic Class
Biguanides
Storage Conditions
Keep below 30°C temperature, protected from light & moisture, Keep out of the reach of children