Itra 50 mg/5 ml (Oral Solution)
Medicine Details
| Category | Details |
|---|---|
| Generic | Itraconazole |
| Company | Square pharmaceuticals plc |
| Also available as |
Title
Itra 50 mg/5 ml Oral Solution
Categories
- Medicine
- Pharmaceuticals
- Antifungal
- Therapeutic Class: Drugs for subcutaneous and mycoses
Description
Itraconazole is used for the treatment of oropharyngeal candidiasis, vulvovaginal candidiasis, pityriasis versicolor, tinea pedis, tinea cruris, tinea corporis, tinea manuum, onychomycosis, histoplasmosis, systemic candidiasis, aspergillosis, cryptococcosis, and maintenance therapy in AIDS patients. It is also used for the prevention of fungal infection during prolonged neutropenia.
DosageAndAdministration
- 100 & 200 mg preparation:
- Non Systemic Fungal Disease:
- Vulvovaginal candidiasis: 200 mg twice daily for 01 day
- Pityriasis versicolor: 200 mg once daily for 07 days
- Tinea corporis, tinea cruris: 100 mg once daily for 15 days or 200 mg once daily for 7 days
- Tinea pedis, tinea manuum: 100 mg once daily for 30 days
- Oropharyngeal candidiasis: 100 mg once daily for 15 days, Increase dose to 200 mg once daily for 15 days in AIDS or neutropenic patients because of impaired absorption
- Onychomycosis: Either 200 mg daily for 3 months or course of 200 mg twice daily for 7 days
- Systemic Fungal Disease:
- Aspergillosis: 200 mg once daily for 2-5 months
- Candidiasis: 100-200 mg once daily for 3 weeks-7 months. Increase dose to 200 mg twice daily in case of invasive or disseminated disease
- Non-meningeal Cryptococcosis: 200 mg once daily for 10 weeks
- Cryptococcal meningitis: 200 mg twice daily for 2-6 months
- Histoplasmosis: 200 mg twice daily for 8 months
- Maintenance in AIDS: 200 mg once daily until immune recovery
- Prophylaxis in neutropenia: 200 mg once daily until immune recovery
- Non Systemic Fungal Disease:
- 65 mg & 130 mg preparation:
- Non Systemic Fungal Disease:
- Vulvovaginal candidiasis: 130 mg twice daily for 1 day
- Pityriasis versicolor: 65 mg twice daily for 7 days
- Tinea corporis and tinea cruris: 65 mg daily for 15 days OR 65 mg twice daily for 7 days
- Tinea pedis and tinea manuum: 65 mg once daily for 30 days
- Oropharyngeal Candidiasis: 65 mg once daily for 15 days, increase dose to 65 mg twice daily for 15 days in AIDS or neutropenic patients because of impaired absorption
- Onychomycosis: Either 65 mg twice daily for 3 months or course of 130 mg twice daily for 7 days
- Systemic Fungal Disease:
- Aspergillosis: 65 mg twice daily for 2-5 months. Increase dose to 130 mg twice daily in case of invasive or disseminated disease
- Candidiasis: 65-130 mg once daily for 3 weeks-7 months. Increase dose to 65 mg twice daily in case of invasive or disseminated disease
- Non-meningeal Cryptococcosis: 65 mg twice daily for 10 weeks
- Cryptococcal meningitis: 130 mg twice daily for 2-6 months
- Histoplasmosis: 130 mg twice daily for 8 months
- Maintenance in AIDS: 65 mg twice daily until immune recovery
- Prophylaxis in neutropenia: 65 mg twice daily until immune recovery
- Non Systemic Fungal Disease:
- Pediatric Use: The efficacy and safety of the Itraconazole capsule have not been established in pediatric patients.
ModeOfAction
Itraconazole inhibits Cytochrome P-450 dependent enzymes resulting in impairing the biosynthesis of ergosterol, a major component of the cell membrane of yeast and fungal cells.
Interaction
Significant interactions observed with drugs like terfenadine, astemizole, cisapride, HMG-CoA reductase inhibitors such as simvastatin, oral midazolam or triazolam. Co-administration of rifampin, phenytoin, phenobarbital, digoxin, and calcium channel blockers may also cause interactions.
Contraindications
Itraconazole is contraindicated in patients with known hypersensitivity to the drug or any ingredient in the formulation. It is not advised for patients with severe hepatic disease and those taking rifampin.
SideEffects
- Nausea
- Abdominal pain
- Dyspepsia
- Constipation
- Headache
- Dizziness
- Raised liver enzymes
- Menstrual disorders
- Allergic reactions
- Hepatitis and cholestatic jaundice
- Peripheral neuropathy
- Stevens-Johnson syndrome
- Hypokalaemia
- Oedema
- Hair loss
PregnancyAndLactation
Itraconazole is contraindicated in pregnancy. Breastfeeding while receiving Itraconazole is not recommended.
PrecautionsAndWarnings
- Absorption: Impaired when gastric acidity is reduced. Acid neutralizing medicines (e.g. aluminium hydroxide) should be administered at least 2 hours after the intake of Itraconazole. It should be administered after a full meal.
- HepatitisAndJaundice: Rarely reported. Monitor liver function in patients receiving continuous treatment of more than one month.
StorageConditions
Store below 25°C, in a cool & dry place. Keep away from light. Keep all the medicine out of the reach of children.
CommonQuestions
- What is Itra 50 mg/5 ml Solution?: An antifungal medication that inhibits Cytochrome P-450 dependent enzymes.
- What is Itra 50 mg/5 ml Solution used for?: To treat fungal infections.
- DurationOfEffect: Lasts up to 16 to 28 hours.
- OnsetOfAction: Peak effect observed in 2 hours.
- PregnancyWarnings: Not recommended for pregnant women. Consult the doctor in case of absolute necessity.
- HabitForming: Not reported to be habit-forming.
- BreastFeedingWarnings: Not recommended for breastfeeding women. Consult the doctor in case of absolute necessity.
- QuickTips:
- Helps treat fungal infections of mouth, skin, vagina or any other parts of the body.
- Do not skip any doses and finish the full course of treatment.
- Take with food, preferably at the same time every day.
- Use reliable contraception to prevent pregnancy.
- Do not take indigestion remedies (antacids) within two hours of taking.
- Doctor may check liver function before starting treatment and regularly thereafter.
- Inform the doctor about allergic reactions, nerve pain, or hearing loss.