Renoxtin 5 mg/ml (IV Infusion)

50 mg vial: ৳ 2,900.00

Medicine Details

Category Details
Generic Oxaliplatin
Company Renata limited

Indications

  • Adjuvant treatment of stage III colon cancer
  • Treatment of advanced colorectal cancer

Pharmacology

  • Formation of reactive species
  • DNA replication and transcription inhibition
  • Cell-cycle nonspecific cytotoxicity
  • Antitumor activity against colon carcinoma

Dosage & Administration

  • Administered in combination with 5-fluorouracil/folinic acid every 2 weeks
  • Treatment duration for advanced disease and adjuvant use
  • Specific dosage and administration instructions for different days

Interaction

  • No specific cytochrome P-450-based drug interaction studies conducted
  • Platinum-containing species elimination through the kidney
  • Potential nephrotoxic compound coadministration

Contraindications

  • Contraindicated in patients with known allergy to oxaliplatin or other platinum compounds

Side Effects

  • Peripheral sensory neuropathy
  • Neutropenia
  • Thrombocytopenia
  • Anemia
  • Nausea
  • Increase in transaminases and alkaline phosphatase
  • Diarrhea
  • Emesis
  • Fatigue
  • Stomatitis
  • Other reported adverse reactions, including serious ones

Pregnancy & Lactation

  • Pregnancy Category D
  • Potential fetal harm
  • No adequate and well-controlled studies in pregnant women
  • Advice for women of childbearing potential
  • Unknown excretion in human milk
  • Consideration for nursing mothers

Precautions & Warnings

  • Grade 3/4 hypersensitivity
  • Neurological toxicity monitoring
  • Acute laryngopharyngeal dysaesthesias management
  • Pulmonary toxicity association
  • Hepatotoxicity and liver function test monitoring
  • Cardiovascular toxicity including QT prolongation and ventricular arrhythmias
  • ECG monitoring recommendations
  • Avoidance in patients with congenital long QT syndrome

Overdose Effects

  • No known antidote for overdose
  • Complications of overdose including hypersensitivity reaction, myelosuppression, nausea, vomiting, diarrhea, and neurotoxicity
  • Cases of reported overdoses
  • Adverse reactions observed in overdose cases
  • Maximum dose administered in a single infusion

Therapeutic Class

  • Cytotoxic Chemotherapy

Storage Conditions

  • Cool and dry place storage
  • Protection from light and moisture
  • Keep out of reach of children

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