Povidone Iodine 10% w/v (Solution)
Medicine Details
| Category | Details |
|---|---|
| Generic | Povidone iodine |
| Company | Ad din pharmaceuticals ltd |
Indications
- Primary or secondary topical infections
- Infected surgical incisions
- Infected decubitus or stasis ulcers
- Pyodermas
- Secondarily infected dermatoses
- Infected traumatic lesions
- Prevent microbial contaminations in burns
- Degerming skin in hyperalimentation
- Use for abrasions, minor cuts, and wounds prevents the development of infections
- Treatment of surface infections
- Treatment for seborrhea
- Preoperative and postoperative scrubbing and washing of hospital operating room and equipments
- Preoperative prepping of operative site, including the vagina
- Disinfection of wounds, burns, lacerations and abrasions
- Prophylactic anti-infective agent in house, hospital & office procedures
- Postoperative application to incisions to help prevent infection
- Oral moniliasis (thrush); bacterial and mycotic skin infections, decubitus & stasis ulcers
- Preoperative swab in the mouth & throat
- Acute mucosal infections of the mouth and pharynx
- Oral hygiene prior to, during and after dental and oral surgery
- Antiseptic skin cleanser for preoperative and postoperative scrubbing and washing by surgeons and operation theatre staff and preoperative preparation of patients' skin
- Superficial wounds
- Minor cuts
- Burns
- Abrasions
- Lacerations
- Dry eye conditions including keratoconjunctivitis sicca
- Substitute for tear fluid in case of unstable tear film or insufficient moistening of the eye surface
Pharmacology
Complex of iodine and an organic polymer, povidone. Prolongs germicidal activity of iodine by liberating elemental iodine slowly. Rapid microbicidal activity against both Gram-positive and Gram-negative bacteria, protozoa, viruses and fungi/yeasts. Sporicidal. Non-staining, exerts prolonged germicidal action and is also active in the presence of soap, blood, serum, pus, mucosal secretions and water.
Dosage & Administration
- Apply once or twice daily or at dressing changes for a maximum of 14 days for treatment of infection
- Apply once or twice a week for as long as necessary for prevention of infection
- Apply full strength as often as needed as paint, spray, or wet soak. Maybe bandaged (where necessary)
- Use undiluted or diluted with an equal volume of warm water. Gargle or rinse with up to 10 mL for up to 30 seconds without swallowing. Repeat up to four times daily, for up to 14 consecutive days, or as advised by the Registered Dental Surgeon/Physician
- Wet hands and forearms with water. Pour about 5 mL of Povidone Iodine Surgical Scrub on the palm of the hand and spread over both hands and forearms. Without adding more water, rub the Scrub thoroughly over all areas for about five minutes. Use a brush if desired. Clean thoroughly under fingernails. Add a little water and develop copious suds. Rinse thoroughly under running water. Complete the wash by scrubbing with another 5 mL of Povidone Iodine Surgical Scrub in the same way
- Apply a light dusting of powder to the affected area. When dry, this forms a protective antiseptic layer over the area treated. Or use as advised by the Registered Physician
- 1 drop 4 times daily or as required, depending upon the severity of the disease, to be instilled into the conjunctival sac
Interaction
Exhibits interaction with strong alkali, sodium thiosulphate, sodium metabisulphite and thiomersal. Use with concurrent lithium therapy has been shown to exhibit hypothyroidic effect.
Contraindications
- Hypersensitivity reactions
- Patients with thyroid disorders
- Patients receiving lithium therapy
- Severely burnt patients
- Serum iodide levels should be assessed in severely burnt patients
- Not to be used in serious cavities and in Children under the age of 2 years
Side Effects
- Hypersensitivity reactions
- Irritation of the skin and mucous membranes
- Systemic adverse effects such as metabolic acidosis, hypernatraemia, and impairment of renal function when applied to severe burns or large denuded areas of skin
- Interference with thyroid function tests
Pregnancy & Lactation
Povidone Iodine Cream, Solution & Powder are not recommended for use during pregnancy because of the possibility of absorption of sufficient iodine to affect the fetal thyroid. American Academy of Pediatrics considers that the use of Povidone-Iodine is usually compatible with breast feeding. Consult Registered Physician. Regular use of Gargle & Mouthwash and Surgical Scrub should also be avoided in pregnant and lactating women. Administation during pregnancy and lactation not recommended except for compelling reasons.
Precautions & Warnings
- In case of deep or puncture wounds or serious burns, consult Registered Physician
- Avoid 'pooling' beneath the patient in preoperative prepping
- Prolonged exposure to wet solution may cause irritation or rarely, severe skin reactions
- Special caution is needed when regular applications to broken skin are made to patients with pre-existing renal insufficiency
- Do not use Gargle & Mouthwash for more than 14 days
- Regular use should be avoided in patients on concurrent lithium therapy
Therapeutic Class
Iodine compounds (Anti-septic Preparations)
Storage Conditions
Store below 25°C. Do not freeze. Store in a cool and dry place, protected from light. Keep out of the reach of children. Do not touch the ophthalmic solution dropper tip to any surface as this may contaminate Povidone Iodine. Do not use it after one month of the first opening.