R-FU 25 mg/ml (IV Injection or Infusion)

250 mg vial: ৳ 60.00

Medicine Details

Category Details
Generic Fluorouracil
Company Renata limited

Indications

  • Carcinoma of the colon or rectum
  • Carcinoma of the stomach and exocrine pancreas
  • Carcinoma of the liver
  • Carcinoma of the breast
  • Carcinoma of the bladder
  • Carcinoma of the lung
  • Epithelial ovarian carcinoma
  • Cervical carcinoma

Pharmacology

  • Metabolic conversion to active form
  • Inhibition of thymidylate kinase
  • Formation of stable complex with folate cofactor
  • Incorporation into RNA
  • Limited effect on proliferative cells
  • Cell cycle effects

Dosage & Administration

  • Intravenous delivery
  • Rapid bolus injection
  • Slow infusion
  • Palliative management dosing
  • Dosage for poor risk patients
  • Maintenance therapy scheduling
  • Pediatric dosing
  • Intra-arterial infusion
  • Combination with radiation
  • Combination with other anticancer drugs

Interaction

  • Pre-treatment with cimetidine

Contraindications

  • Severe debilitation
  • Bone marrow suppression
  • Pregnancy
  • Breastfeeding
  • Non-malignant illnesses

Side Effects

  • Cardiac effects
  • Hematological effects
  • Neurological effects
  • Allergic reaction
  • Hand-foot syndrome
  • Vomiting and diarrhea
  • Mild to moderate nausea
  • Rash and itching
  • Temporary hair loss
  • Conjunctivitis
  • Hematological toxicity

Pregnancy & Lactation

  • Teratogenic risk
  • Contraindicated throughout pregnancy
  • Inhibition of DNA, RNA, and protein synthesis
  • Excretion in human milk
  • Nursing prohibition

Precautions & Warnings

  • Highly toxic with narrow safety margin
  • Therapeutic response linkage to toxicity
  • Dose limitations
  • Prompt discontinuation upon toxicity signs
  • Careful supervision
  • Leucopenia
  • Thrombocytopenia
  • Stomatitis
  • Severe diarrhea
  • Gastro-intestinal ulceration and bleeding

Use in Special Populations

  • Neonates
  • Children
  • The elderly

Overdose Effects

  • Deliberate overdose cases
  • Excessive toxicity
  • No specific antidote
  • Supportive care treatment

Reconstitution

  • Specialized handling
  • Room reservation for reconstitution
  • Required equipment
  • Skin contact precautions
  • Mucous membranes contact precautions
  • Pregnant women warning
  • Contaminated waste disposal

Storage Conditions

  • Storage temperature
  • Original carton storage
  • Protection from light

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