Utrogest 100 mg (Capsule)
Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)
Strip Price: ৳ 150.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Progesterone micronized capsule |
| Company | Ziska pharmaceuticals ltd |
| Also available as |
Category
- Medicine
- Pharmacology
- Dosage & Administration
- Interaction
- Contraindications
- Side Effects
- Precautions & Warnings
- Therapeutic Class
- Storage Conditions
Title
- Utrogest Softgel Capsule
- Progesterone Micronized Softgel Capsule
- Progesterone 100 mg/200 mg
Indications
- Maintenance of pregnancy in cases of threatened/recurrent abortion
- Luteal support during IUI and ART procedures IVF-ET
- Luteal support in cases of proven luteal phase insufficiency
- Post-menopausal hormone replacement therapy (HRT)
- Prevent endometrial hyperplasia where endogenous estrogen is present
- Progesterone challenge test in secondary amenorrhoea
- Cycle control along with estrogen therapy
- Dysfunctional uterine bleeding (DUB)
- Premenstrual tension
- Endometriosis
- Oocyte donation programme
- Benign mastopathy
Pharmacology
- Contains micronised progesterone structurally and biologically identical to natural endogenous progesterone
- Micronisation increases the bioavailability of progesterone
- Maximal serum progesterone levels significantly increased when administered after meals
- Progesterone concentrations in endometrial and breast tissue attain high level
- Approximately 96%-99% of progesterone bound to serum proteins, primarily to serum albumin (50%-54%)
- Metabolized to pregnanediols and pregnanolones in the liver
- Glucuronide and sulfate conjugates of pregnanediol and pregnanolone excreted in bile and urine
- Metabolites may undergo enterohepatic circulation
Dosage & Administration
- Usual recommended dose of Progesterone 100 mg/200 mg
- Oral or vaginal routes of administration
- Flexible dosage regimen depending on the indication and patient's requirements
- Specific dosages for different indications including maintenance of pregnancy, in-vitro fertilization, HRT, luteal support, luteal phase insufficiency, secondary amenorrhoea, premenstrual syndrome, and benign mastopathy
Interaction
- Ketoconazole inhibits the metabolism of progesterone
Contraindications
- Hypersensitivity
- Hepatic dysfunction
- Undiagnosed vaginal bleeding
- Porphyria
- Cancers of uterus and genital organs
- Breast cancers
- History of stroke or blood clots
- Miscarriage and tissue left in the uterus
Side Effects
- Mild somnolence
- CNS side effects like depression
- Breast tenderness
- Bloating
- Less pronounced side effects when using the vaginal route
Precautions & Warnings
- Severe renal insufficiency
- Diabetes mellitus
- Seizures
- Migraine
- Headache
- Heart diseases
- Depression
Therapeutic Class
- Drugs for menopausal symptoms
- Hormone replacement therapy
- Female sex hormones
- Oral contraceptive preparations
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of the reach of children