Erenzo 20 mg (Tablet)
Unit Price: ৳ 200.00 (1 x 10: ৳ 2,000.00)
Strip Price: ৳ 2,000.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Roxadustat |
| Company | Unimed unihealth pharmaceuticals ltd |
| Also available as |
Title
- Erenzo
- Roxadustat
Categories
- Medications
- Anemia Treatments
- Pharmaceuticals
Description
- First-in-class orally administered HIF-PH inhibitor
- Promotes erythropoiesis through increasing endogenous production of erythropoietin
- Improves iron regulation
- Overcomes the EPO-suppressive effects of inflammation on hemoglobin synthesis and red blood cell production by downregulating hepcidin
Indications
- Treatment of adult patients with symptomatic anemia associated with chronic kidney disease (CKD)
Pharmacology
- Orally bioavailable
- Hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI)
- Binds to and inhibits HIF-PH
- Prevents HIF breakdown and promotes HIF activity
- Increases endogenous erythropoietin production
- Reduces hepcidin expression
- Improves iron availability
- Boosts hemoglobin (Hb) levels
Dosage & Administration
- Orally administered three times per week
- Individualized dose to achieve and maintain target Hb levels of 10 to 12 g/dL
- Different starting doses for patients not on erythropoiesis-stimulating agent treatment and for those switching from such agents
- Dose adjustments based on Hb monitoring
- Table for stepwise dose adjustments
Interaction
- Potential drug-drug interactions with phosphate binders and other products containing multivalent cation, gemfibrozil, probenecid, OATP1B1, BCRP substrates
- Recommendations for dose adjustments based on specific interactions
Side Effects
- Common adverse reactions include hypertension, vascular access thrombosis, diarrhea, peripheral edema, hyperkalemia, and nausea
Pregnancy & Lactation
- Contraindicated during pregnancy
- Contradicted during breast-feeding
Precautions & Warnings
- Caution in use, particularly in patients with pre-existing risk factors for thrombotic vascular events (TVEs), history of seizures, serious signs and symptoms of infection, or liver disorders
- Not to be initiated in pregnant women
Use in Special Populations
- Not indicated in children
- Not recommended for use in patients with severe hepatic impairment
Overdose Effects
- Symptoms of overdose include increased heart rate transient and likely excessive increase in hemoglobin concentration
- Treatment involves appropriate measures of dose reduction or interruption
Therapeutic Class
- Drugs for Haemolytic Hypoplastic & Renal Anemia
Storage Conditions
- Store below 30°C, in a cool, dry place, away from light and moisture
- Keep out of the reach of children