Erenzo 50 mg (Tablet)
Unit Price: ৳ 350.00 (1 x 10: ৳ 3,500.00)
Strip Price: ৳ 3,500.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Roxadustat |
| Company | Unimed unihealth pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of symptomatic anemia associated with chronic kidney disease (CKD) in adult patients
Description
- First-in-class orally administered HIF-PH inhibitor
- Promotes erythropoiesis through increasing endogenous production of erythropoietin
- Improves iron regulation
- Overcomes EPO-suppressive effects of inflammation on hemoglobin synthesis and red blood cell production by downregulating hepcidin
Pharmacology
- Orally bioavailable
- Hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI)
- Binds to and inhibits HIF-PH
- Increases endogenous erythropoietin production
- Reduces expression of hepcidin
- Improves iron availability
- Boosts hemoglobin (Hb) levels
- Regulates genes required for erythropoiesis and iron metabolism
Dosage & Administration
- Oral administration
- Taken three times per week
- Individualized dose to achieve and maintain target Hb levels of 10 to 12 g/dL
- Dosing based on erythropoiesis-stimulating agent treatment
- Dose adjustments based on Hb monitoring
- Missed dose instructions
- Can be taken with or without food
Interaction
- Drug-drug interactions with phosphate binders, gemfibrozil, probenecid, OATP1B1, BCRP substrates
- Specific risks and recommendations for each interaction
Side Effects
- Common adverse reactions: hypertension, vascular access thrombosis, diarrhea, peripheral edema, hyperkalemia, nausea
Pregnancy & Lactation
- Contraindicated during pregnancy or breastfeeding
Precautions & Warnings
- Initiation caution
- Potential to initiate thrombotic vascular events (TVEs)
- Caution in patients with history of seizures
- Avoid use in serious signs and symptoms of infection or liver disorder
- Not to be initiated in pregnant women
Use in Special Populations
- Not indicated for use in children
- Not recommended for patients with severe hepatic impairment
Overdose Effects
- Symptoms of overdose
- Treatment measures for overdose
- Not removed by dialysis
Therapeutic Class
- Drugs for Haemolytic Hypoplastic & Renal Anemia
Storage Conditions
- Store in a cool, dry place below 30°C
- Keep away from light and moisture
- Keep out of reach of children