Erenzo 100 mg (Tablet)
Unit Price: ৳ 600.00 (1 x 3: ৳ 1,800.00)
Strip Price: ৳ 1,800.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Roxadustat |
| Company | Unimed unihealth pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of symptomatic anemia associated with chronic kidney disease (CKD) in adult patients
Description
- First-in-class orally administered HIF-PH inhibitor
- Promotes erythropoiesis
- Increases endogenous production of erythropoietin
- Improves iron regulation
- Downregulates hepcidin to overcome EPO-suppressive effects of inflammation on hemoglobin synthesis and red blood cell production
Pharmacology
- Orally bioavailable hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI)
- Binds to and inhibits HIF-PH
- Prevents HIF breakdown and promotes HIF activity
- Increases endogenous erythropoietin production
- Reduces expression of hepcidin
- Improves iron availability
- Boosts hemoglobin (Hb) levels
Dosage & Administration
- Oral administration three times per week
- Individualized dose to achieve and maintain target Hb levels of 10 to 12 g/dL
- Different starting doses for patients not on erythropoiesis-stimulating agent treatment and those switching from such agents
- Dose adjustment rules based on Hb monitoring
- Specific sequence for stepwise dose adjustments
- Guidelines for missed dose
- Oral intake with or without food
Interaction
- Potential drug-drug interactions with phosphate binders, gemfibrozil, probenecid, and certain substrates (simvastatin, rosuvastatin, atorvastatin) leading to altered AUC and Cmax levels
- Recommendations for dosing adjustment based on specific interactions
Side Effects
- Common adverse reactions include hypertension, vascular access thrombosis, diarrhea, peripheral edema, hyperkalemia, and nausea
Pregnancy & Lactation
- Contraindicated in women who may be pregnant or pregnant
- Contraindicated during breastfeeding
Precautions & Warnings
- Caution required due to potential initiation of thrombotic vascular events (TVEs)
- Specific caution for patients with pre-existing risk factors for TVE, history of seizures, serious signs of infection, or liver disorder
Use in Special Populations
- Not indicated for use in children
- Not recommended for use in patients with severe hepatic impairment
Overdose Effects
- Symptoms include increased heart rate transient and likely excessive increase in hemoglobin concentration
- Treatment involves appropriate dose reduction or interruption, not removed by dialysis
Therapeutic Class
- Drugs for Haemolytic Hypoplastic & Renal Anemia
Storage Conditions
- Store in a cool, dry place below 30°C, away from light and moisture
- Keep out of the reach of children