Ephidin 25 mg/5 ml (Injection)
5 ml ampoule: ৳ 25.00 (2 x 5: ৳ 250.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ephedrine hydrochloride |
| Company | Popular pharmaceuticals ltd |
Indications
- Reverse hypotension induced by spinal or epidural anaesthesia
Pharmacology
- Stimulant drug
- Alpha and beta adrenergic agonist
- Enhances release of norepinephrine
- Increases activity of central nervous system
Dosage & Administration
- 3 to 6 mg Ephedrine Hydrochloride for hypotension reversal
- Intravenous injection
- Maximum total dose of 30 mg
- Can be given by intramuscular or subcutaneous injection
Interaction
- May cause hypertensive crisis with Monoamine Oxidase Inhibitor
- Avoid or use with care in patients undergoing anaesthesia with volatile anaesthetics
- Increased risk of arrhythmias in patients receiving cardiac glycosides, quinidine, or tricyclic antidepressants
- Increased risk of vasoconstriction or pressor effects in patients receiving ergot alkaloids or oxytocin
Contraindications
- Contraindicated in presence of coronary thrombosis
- Caution in patients with organic heart disease, cardiac decompensation, hyperthyroidism, hypertension, and angina pectoris
- Caution in patients receiving digitalis
Side Effects
- Nausea
- Vomiting
- Anorexia
- Tachycardia
- Arrhythmias
- Anginal pain
- Hypertension
- Hypotension
- Dizziness
- Flushing
- Dyspnoea
- Headache
- Anxiety
- Restlessness
- Confusion
- Psychoses
- Insomnia
- Tremor
- Difficulty in micturition
- Urine retention
- Sweating
- Hypersalivation
- Changes in blood-glucose concentration
- Rarely angle-closure glaucoma
Pregnancy & Lactation
- Category C in Pregnancy
- Not recommended for use during lactation due to risk of adverse effects in the infant
Precautions & Warnings
- Care with hyperthyroidism, diabetes mellitus, ischemic heart disease, hypertension, renal impairment, or angle-close glaucoma
- May increase difficulty with micturition in patients with prostatic enlargement
- Increased fetal heart rate reported with parenteral use
- Irritability and disturbed sleep reported in breast-fed infants
Overdose Effects
- Giddiness
- Headache
- Nausea
- Vomiting
- Sweating
- Palpitations
- Difficulty in micturition
- Tremors
- Anxiety
- Restlessness
- Insomnia
Therapeutic Class
- Adrenoceptor stimulants
- Vasoconstrictor/Venotonic
Storage Conditions
- Store in a cool, dry place
- Protected from light
- Keep out of reach of children